Etiology To date, mutations in three genes have been demonstrated to cause familial CCM; KRIT1, CCM2 and PDCD10, located on chromosome 7q21.2, 7p13, and 3q26.1 respectively
[orpha.net]
Researchers have identified genetic mutations that can cause cerebral cavernous malformations, such as the genes KRIT1 (CCM1), CCM2 and PDCD10 (CCM3).
[aans.org]
Genetic studies show that specific gene mutations or deletions are causes for the disease.
[en.wikipedia.org]