Early Onset: Causes & Reasons

Possible Causes for Early Onset

GLC1P is characterized by early onset, thin central corneas and low intraocular pressure. [uniprot.org]

As discussed above, one set of mutations in the myocilin gene are known to cause early onset glaucoma (JOAG). [medrounds.org]

Common findings among JOAG patients include early onset of disease, very high IOP and a strong family history of glaucoma. 3,4 Histopathologic study of the trabecular meshwork [reviewofophthalmology.com]

Dysthymic Disorder

CONCLUSIONS: In the elderly, late-onset DD is typically different from early onset DD. Cerebrovascular disease appears to play a role in the etiology of late onset DD. [ncbi.nlm.nih.gov]

The present study addressed this issue using a sample of 97 adult outpatients with early-onset DD, 45 adult outpatients with episodic MDD, and 45 normal controls, and their [ncbi.nlm.nih.gov]

This article reports the major findings from a prospective, longitudinal 30-month follow-up study of 86 outpatients with early-onset DD (EOD) and 39 outpatients with episodic [ncbi.nlm.nih.gov]

Scoliosis

The Scoliosis Research Society has published a consensus statement on early onset scoliosis ( Spine Deformity 3 (2015) p.107): Download the Early Onset Scoliosis Frequently [srs.org]

Early Onset Scoliosis (Infantile Scoliosis) Early onset scoliosis is the abnormal, side-to-side curve of spine in children under 5 years old. [cincinnatichildrens.org]

The Scoliosis Research Society has published a consensus statement on early onset scoliosis ( Spine Deformity 3 (2015) p.107): Early Onset Scoliosis refers to spine deformity [web.archive.org]

Alzheimer Disease

Early onset dementia: Frequency and causes in comparison to late onset dementia. [oadoi.org]

Early-onset AD can be due to mutations in several autosomal dominant genes. [ncbi.nlm.nih.gov]

OBJECTIVE: This study was undertaken to clarify the genetics of very early onset Alzheimer disease (VEOAD), defined as AD beginning before age 35. [ncbi.nlm.nih.gov]

Late-Onset Depression

Early-onset /early-resolving AD, occurring in 13%-15% of the children, was most prevalent and was associated with male gender. [medical-dictionary.thefreedictionary.com]

They were divided into two groups according to the age of onset of depression: Late Onset Depression (LOD) group and Early Onset Depression (EOD) group. [eurekaselect.com]

Although the incidence of young-onset T2DM is increasing, it is still not fully clear the onset characteristics and risk factors of early-onset T2DM. [medical-dictionary.thefreedictionary.com]

Malignant Neoplasm of the Prostate

Currently, there is no national consensus regarding the definition of early-onset prostate cancer. The definition of 'early onset' varies depending on the study. [medscape.com]

METHODS: In a study of brothers discordant for the diagnosis of prostate cancer (including 449 affected and 394 unaffected men) from 332 familial and early-onset prostate [ncbi.nlm.nih.gov]

[…] cancer, we tested for prostate cancer association with 6 of these 7 markers in a sample of 1,015 non-Hispanic white men with and without prostate cancer from 403 familial and early-onset [ncbi.nlm.nih.gov]

Pallido-Pyramidal Syndrome

Early-onset cases that begin before age 20 may be referred to as juvenile-onset disease. [flybase.org]

MalaCards based summary : Parkinson Disease 15, Autosomal Recessive Early-Onset, also known as pallidopyramidal syndrome, is related to complex hereditary spastic paraplegia [malacards.org]

[…] phenotype Parkinson disease 15 is an early-onset form of the disorder. [flybase.org]

Waisman Syndrome

onset with mental retardation, basal ganglia disorder with mental retardation, Parkinsonism, early-onset, with mental retardation, WAISMAN syndrome, Waisman syndrome Annotation [monarchinitiative.org]

"Mutations in RAB39B cause X-linked intellectual disability and early-onset Parkinson disease with α-synuclein pathology". [en.wikipedia.org]

[…] disability characterized by infantile-onset non-progressive intellectual deficit (with psychomotor developmental delay, cognitive impairment and macrocephaly) and early-onset [orpha.net]

Alcohol Dementia

The association was particularly strong for those with early-onset dementia, diagnosed when the patient is younger than 65. [edition.cnn.com]

During that time, 487 men developed early-onset dementia, at an average age of 54. [drugfree.org]

For early-onset dementia, there was a significant gender split. [sciencedaily.com]

Sepsis in Premature Infants

[…] sepsis]….Recognition of differential [early-onset sepsis ] risk may help guide early empirical antibiotic use among approximately one-third of extremely preterm infants.” [infectiousdiseaseadvisor.com]

TABLE 1 Invasive early-onset a neonatal sepsis cases and deaths, Active Bacterial Core Surveillance Program, 2005 to 2008 b Organisms causing early-onset neonatal sepsis are [cmr.asm.org]

BACKGROUND: Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. [ncbi.nlm.nih.gov]

Umbilical Sepsis

Neonatal sepsis in the neonatal intensive care unit: characteristics of early versus late onset. J Microbiol Immunol Infect. 2004;37:301-6. [ijpediatrics.com]

Early-onset neonatal sepsis. Clin. Microbiol. Rev. 27, 21–47 (2014). Article PubMed PubMed Central Google Scholar Stoll, B. J. et al. [nature.com]

Early-onset sepsis (EOS) due to invasive bacterial infection is a leading cause of morbidity in infants and disproportionately affects those born preterm. [grantome.com]

Hereditary Leiomyomatosis and Renal Cell Cancer

Affected females generally present with early onset, atypical uterine leiomyomas and cutaneous findings, however, delays in diagnosis are very common in patients with isolated [ncbi.nlm.nih.gov]

In view of the potential for early onset of RCC in HLRCC, periodic renal imaging and, when available, predictive testing for a FH mutation is recommended from 8 to 10 years [ncbi.nlm.nih.gov]

Susceptibility to early-onset renal cell carcinoma and uterine leiomyosarcoma is present in a subset of families. [eurekaselect.com]

Progressive Myoclonic Epilepsy Type 3

The onset is in early infancy, and death occurs in the first decade. [tandfonline.com]

onset. [malacards.org]

Overview Epilepsy, progressive myoclonic 3: A genetic disorder involving the early onset of progressive myoclonic epilepsy. [checkorphan.org]

Familial Infantile Myoclonic Epilepsy

Early-onset myoclonic epilepsy with focal and generalized myoclonic seizures is a common characteristic of this continuum. [ncbi.nlm.nih.gov]

Autosomal recessive early onset epilepsy 24995870 SLC1A2 Epileptic encephalopathy pending SLC25A22 Early onset epileptic encephalopathy 21967765 SLC2A1 GLUT1 deficiency syndrome [tests.labmed.washington.edu]

Early-onset myoclonic seizures, focal epilepsy, dysarthria, and mild-to-moderate intellectual disability. Progressive myoclonus epilepsy (PME). [ncbi.nlm.nih.gov]

Non-Syndromic Ocular Stickler Syndrome Type 1

Abstract Purpose: Our previous study reported that 5.5% of probands with early-onset high myopia (eoHM) had mutations in COL2A1 or COL11A1. [molvis.org]

onset arthritis. [hindawi.com]

Chapter 41 Hereditary Vitreoretinal Degenerations Hereditary vitreoretinal degeneration, also known as hereditary vitreoretinopathy, is classically characterized by early-onset [clinicalgate.com]

X-Linked Parkinsonism with Spasticity

onset [asperbio.com]

Gene Location Designation Mode of Inheritance Clinical Characteristics DYT-1 (TOR1A) 9q34 Early Onset Primary Dystonia Autosomal Dominant Early-onset, Starts in a limb in [cmdg.org]

[…] dystonia-parkinsonism DYT13 – Cranial-cervical dystonia DYT15 – Myoclonus-dystonia DYT16 – Early-onset generalized-parkinsonism DYT17 – Early-onset dystonia DYT18 – Paroxysmal [dystonia.ie]

Streptococcus Agalactiae

In the present case, the patient had both early and late onset GBS disease. [hindawi.com]

Cases of early onset disease caused by type Ia, III, or V GBS were identified by prospective, multicenter, laboratory-based surveillance for invasive early onset GBS disease [doi.org]

Summary of Risk of Early-Onset Group B Streptococcus by Intrapartum Antibiotic Prophylaxis Policy a IAP Policy No. of GBS- Colonized Mothers No. of Early- Onset GBS Cases [doi.org]

Benign Familial Infantile Epilepsy Type 4

Onset Seizures: Case Report and Revision of Literature Data. 61 Laccetta G...Ghirri P 31552204 2019 6 Kv7.3 Compound Heterozygous Variants in Early Onset Encephalopathy Reveal [malacards.org]

Here, we report the case of an infant and her father with early onset benign familial infantile epilepsy, but without cognitive or neurological impairment. [ncbi.nlm.nih.gov]

Streptococcal Septicemia

A significant increase in the number of infants contracting early-onset GBS-septicemia was noticed at one clinic in 1981, from 1-3 cases per yr to 8 cases. [ncbi.nlm.nih.gov]

Abstract A retrospective investigation was made to determine the incidence of early onset group B streptococcal (GBS) septicemia in Sweden in relation to perinatal data. [ncbi.nlm.nih.gov]

Factors Associated With Early-Onset Disease The primary risk factor for early-onset group B streptococcal infection is maternal intrapartum rectovaginal colonization with [acog.org]

Nosocomial Pneumonia

Patient risk factors for MDR pathogens Onset of HAP Local resistance patterns What are the potential pathogens in early-onset HAP, and no risk factors for MDRs? [quizlet.com]

Treatment and prognosis The early onset type has a better prognosis. [radiopaedia.org]

Strep pneumo H. flu MSSA Enteric gram-negatives What are the recommended antibiotics for early-onset HAP/no RF's for MDR? [quizlet.com]

Distal Spinal Muscular Atrophy Type 5

In accordance with previous reports, a mutation in Ser331 in the present patient was associated with early-onset and a severe phenotype. [spandidos-publications.com]

early childhood-onset disability, respectively. [journals.plos.org]

[…] infantile epileptic encephalopathy Early myoclonic encephalopathy Early-onset spastic ataxia-neuropathy syndrome Epidermolysis bullosa simplex with muscular dystrophy Epidermolysis [csbg.cnb.csic.es]

Wolcott-Rallison Syndrome

[…] syndrome due to the same mutation in EIF2AK3 (c.205G>T) in two unrelated families: A case report. 61 Huang A...Wei H 30906465 2019 24 EIF2AK3 novel mutation in a child with early-onset [malacards.org]

The cardinal features of the syndrome include early-onset insulin-dependent diabetes mellitus, multiple epiphyseal dysplasia, and growth retardation. [ncbi.nlm.nih.gov]

Microcephaly and simplified gyral pattern of the brain associated with early onset insulin-dependent diabetes mellitus. Neurogenetics 2006;7:259–63. [degruyter.com]

Neonatal Infection

After the Birth If there are any risk factors for early-onset neonatal infection (see Table 1, above) or if there are clinical indicators of possible early-onset neonatal [web.archive.org]

KEYWORDS: C-reactive protein; antibiotic therapy; early-onset neonatal sepsis; procalcitonin; white blood cell count [ncbi.nlm.nih.gov]

Keywords newborn; early-onset sepsis; early-onset neonatal infection; group B Streptococcus; risk factors Full Text: PDF Number of abstract views: 3311 Number of PDF views [jpnim.com]

Chorioamnionitis

Chorioamnionitis and Funisitis Increase the Risk of Preterm Labor and Early Onset Neonatal Sepsis. Biomed Pharmacol J 2017;10(2). [biomedpharmajournal.org]

TABLE 5 Maternal Risk Factors for Early-Onset GBS Sepsis at the Time of Delivery and Maternal Clinical Signs Within 72 Hours Before Delivery for Infants With Invasive Early-Onset [pediatrics.aappublications.org]

OBJECTIVE: This study aims to determine whether preterm prolonged rupture of membranes (PPROM) increases the risk for early-onset sepsis (EOS) in preterm infants. [ncbi.nlm.nih.gov]

Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is one of the most penetrant forms of familial cancer susceptibility syndromes, characterized by early age at tumor onset and a wide spectrum of [ncbi.nlm.nih.gov]

Germline mutations in the TP53 gene predispose individuals to various tumours associated with LFS including early onset sarcomas and breast cancer, osteosarcomas, brain cancer [sickkids.ca]

Li-Fraumeni Syndrome (LFS) is characterized by early-onset carcinogenesis involving multiple tumor types and shows autosomal dominant inheritance. [ncbi.nlm.nih.gov]

Neonatal Sepsis

TABLE 1 Invasive early-onset a neonatal sepsis cases and deaths, Active Bacterial Core Surveillance Program, 2005 to 2008 b Organisms causing early-onset neonatal sepsis are [cmr.asm.org]

Escherichia coli early-onset sepsis: trends over two decades. Eur J Pediatr 2017;176(9):1227-34. P868 [imj.ie]

Preterm birth/low birth weight is the risk factor most closely associated with early-onset sepsis. 17 Infant birth weight is inversely related to risk of early-onset sepsis [pediatrics.aappublications.org]

Infantile-Onset Ascending Hereditary Spastic Paralysis

Infantile-onset ascending hereditary spastic paralysis (IAHSP) is a rare, early-onset autosomal recessive motor neuron disease associated with mutations in ALS2. [ncbi.nlm.nih.gov]

DOI: 10.1016/j.ejpn.2013.09.009 Abstract Background: Infantile-onset ascending hereditary spastic paralysis (IAHSP) is a rare, early-onset autosomal recessive motor neuron [eprints.uniss.it]

Recessive mutations in ALS2 (juvenile amyotrophic lateral sclerosis) are causative for early-onset upper motor neuron diseases, including infantile ascending hereditary spastic [scienceopen.com]

Neonatal Meningitis

RESULTS: There were 852 babies with early onset sepsis, of whom 78 (9.2%) had EONBM. [ncbi.nlm.nih.gov]

We describe here what is believed to be the first reported case of early onset meningitis due to 'L. amnionii' in a neonate with intrauterine growth retardation. [ncbi.nlm.nih.gov]

Her diagnosis was early-onset neonatal sepsis and meningitis caused by L monocytogenes based on her CSF gram stain, blood culture results, and clinical presentation. [academic.oup.com]

Maturity-Onset Diabetes of the Young

AIMS: PAX4 R192H polymorphism was reported to be associated with maturity onset diabetes of the young (MODY) and early onset-age of type 2 diabetes (T2D). [ncbi.nlm.nih.gov]

It represents 95% of all cases of diabetes in Spain among patients under 20 years of age.2 Maturity onset diabetes of the young (MODY) is a monogenic form of familial early [elsevier.es]

The first to be identified was a syndrome of early onset dominantly inherited diabetes titled MODY (maturity onset diabetes of the young), which accounts for up to 2% of all [diapedia.org]

Renal Cysts and Diabetes Syndrome

AIMS/HYPOTHESIS: Mutations in the hepatocyte nuclear factor-1 beta ( HNF-1 beta) gene result in disorders of renal development, typically involving renal cysts and early-onset [ncbi.nlm.nih.gov]

More information Clinical presentations: - Unexplained familial renal cystic disease - Renal cysts may be detected in utero - Early onset non-insulin dependent diabetes - [ceed3.org]

Continue » The disease is characterised by a renal developmental disorder and early-onset diabetes usually in young adults. [bioscientia-humangenetik.de]