Liver Dysfunction: Causes & Reasons

Possible Causes for Liver Dysfunction

Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome

dysfunction (unexplained elevation of liver transaminases with or without mild coagulopathy, with or without mild hyperammonemia and protein intolerance). [hero.epa.gov]

It has variable clinical presentations with episodic hyperammonemia, liver dysfunction, and chronic neurological manifestations. [ncbi.nlm.nih.gov]

It is characterized by lethargy, poor feeding, vomiting, encephalopathy and liver dysfunction. [lalpathlabs.com]

Zellweger Syndrome

Liver dysfunction may be evident as neonatal jaundice and elevation in liver function tests. [path.upmc.edu]

It is characterized by severe hypotonia, failure to thrive, psychomotor retardation, liver dysfunction, and sensorineural hearing impairment. [ncbi.nlm.nih.gov]

Her delayed neurological development, liver dysfunction, and cholestasis were all improved 2 weeks after starting the dietary treatment. [ncbi.nlm.nih.gov]

Budd-Chiari Syndrome

[…] findings on biopsy Terminology Also called hepatic vein thrombosis Historically, Budd-Chiari syndrome technically referred to the triad of painful hepatomegaly, ascites and liver [pathologyoutlines.com]

Congestive hepatopathy, is liver dysfunction due to venous congestion, usually due to congestive heart failure. [en.wikipedia.org]

She had no past medical history, including no history of liver dysfunction. [casereports.in]

Carnitine Transporter Deficiency

dysfunction. [en.wikipedia.org]

Symptoms: seizures, dementia, spasticity, blindness, liver dysfunction, and cerebral degeneration. Source: Dr. Rolf Luft; The development of mitochondrial medicine. [umdf.org]

During periods of fasting, fatty acids are also an important energy source for the liver and other tissues. [ghr.nlm.nih.gov]

Disorder of Iron Metabolism

Transferrin saturation above normal range in male and female also need additional testing.Chemical evidence of tissue vitamin C deficiency and mild to moderate liver dysfunction [en.wikipedia.org]

People with the following signs and symptoms may also have this test: Diabetes Elevated liver enzymes Erectile dysfunction, or male impotence Extreme tiredness Heart disease [medicalnewstoday.com]

[…] anaemia (Such as thal major or myelodysplasia • Each unit of blood contains 250mg or iron List some clinical features of iron overload • These are mainly caused by organ dysfunction [quizlet.com]

Cytomegalovirus Infection

[…] of drug-associated liver dysfunction, a probable CMV hepatitis category is not defined. [academic.oup.com]

OUTCOME CMV infection is associated with (Limaye et al, 2010; Ong et al, 2016): increased organ dysfunction (liver and renal) prolonged ICU stay increased duration of mechanical [lifeinthefastlane.com]

A comprehensive evaluation for liver disease was notable for a markedly elevated ferritin level. [ncbi.nlm.nih.gov]

Pylephlebitis

In advanced cases appears liver dysfunction and jaundice. [scielo.isciii.es]

Other exam findings of chronic liver disease are seen in the setting of cirrhotic PVT but are relatively uncommon in non-cirrhotic PVT. E. [clinicaladvisor.com]

The rare complication of portal cholangiopathy – biliary dysfunction in the setting of portal hypertension – may result in jaundice, abdominal tenderness due to biliary colic [clinicaladvisor.com]

Anabolic Steroid

Keywords: Anabolic androgenic steroids, immune system, cytokines, estrogen, T cells, testosterone, platelet aggregation, stroke, liver dysfunction, side effects, athletes, [doi.org]

dysfunction. [ncbi.nlm.nih.gov]

dysfunction, myocardial infarction and potentially stroke, due to its ability to increase platelet and platelet aggregation. [doi.org]

T-Cell Lymphoma

The present case may shed light on of the mechanisms of liver dysfunction accompanying AITL. [ncbi.nlm.nih.gov]

CASE PRESENTATION: Case one is a 19-year-old female presented with fever and liver dysfunction, and was diagnosed as EBV-associated chronic active hepatitis. [ncbi.nlm.nih.gov]

The condition may lead to liver dysfunction and even multi-organ failure. [symptoma.com]

Celecoxib

A 50 percent dose reduction is recommended in patients with moderate liver dysfunction. [ems1.com]

dysfunction, concurrent diuretic, or ACE inhibitor therapy (↑ risk of renal impairment); Hypertension or fluid retention; Renal impairment (may precipitate acute renal failure [drugguide.com]

dysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers Anemia may occur; monitor hemoglobin [reference.medscape.com]

Angiotensin-Converting Enzyme Inhibitor

There are serious side effects of this drug like kidney failure, severe allergic reactions, and liver dysfunction or failure. [medicinenet.com]

Common side effects include dizziness, hyperkalemia, and headache, while less common side effects include diarrhea, liver dysfunction, back pain, muscle cramp, renal impairment [news-medical.net]

There are serious side effects of this drug like kidney failure, severe allergic reactions, and liver dysfunction, or failure. [medicinenet.com]

Wolcott-Rallison Syndrome

It is associated with liver dysfunction, epiphyseal dysplasia, and developmental delay. [unboundmedicine.com]

Liver enzymes (AST (blue) and ALT (red)) during the patient's first (left panel) and most severe (right panel) exacerbations of liver dysfunction Endocrine pancreatic function [onlinelibrary.wiley.com]

The initial exacerbation of severe liver dysfunction subsided after 10 days with complete biochemical resolution including LFTs and neutrophils (Figure 1). [onlinelibrary.wiley.com]

Isoniazid Hepatitis

The incidence of liver dysfunction in our patients considerably exceeds the reported incidence of hepatotoxicity of INH treatment. 5– 7 Interference with DMARD treatment, [ard.bmj.com]

Chronic liver disease. Perform LFTs prior to therapy, then periodically as needed. Severe renal dysfunction. >35yrs old. [clinicaladvisor.com]

Dickinson DS, Bailey WC, Hirschowitz BI, Soong SJ, Eidus L, Hodgkin MM: Risk factors for isoniazid (INH)-induced liver dysfunction. [link.springer.com]

Venous Air Embolism

To report a non-fatal case of intraoperative venous air embolism (VAE) during an awake craniotomy. VAE presented with unusual clinical features. VAE during an awake craniotomy has not been reported frequently. The patient we describe presented with persistent coughing followed by tachypnea, hypoxia and reduction[…] [ncbi.nlm.nih.gov]

Acute Fatty Liver of Pregnancy

Postpartum Acute Liver Dysfunction: A Case of Acute Fatty Liver of Pregnancy Developing Massive Intrahepatic Calcification Abstract The function of the liver is particularly [gastrores.org]

Published works dealing with liver dysfunction in pregnancy, HELLP syndrome and AFLP were reviewed. [ncbi.nlm.nih.gov]

Anesthetic implications include early recognition of liver dysfunction and aggressive resuscitation and treatment of hypoglycemia, disseminated intravascular coagulopathy, [ncbi.nlm.nih.gov]

Acute Infantile Liver Failure-Multisystemic Involvement Syndrome

Severe liver dysfunction in an infant with cystic fibrosis masquerading as metabolic liver disease. [ijpmonline.org]

In conclusion, mitochondrial dysfunction is common in severe liver failure in non-mitochondrial conditions. [link.springer.com]

[…] of pediatric and adult-onset disease Childhood mitochondrial disease is typically more severe than adult-onset disease and includes progressive neurological, cardiac, and liver [bcmj.org]

Neonatal Adrenoleukodystrophy

dysfunction or leukodystrophy. [orpha.net]

[…] other PBD-ZSS disorders (see these terms), single enzyme defects in peroxisome fatty acid beta-oxidation, and disorders that feature severe hypotonia, neonatal seizures, liver [orpha.net]

Hepatic Encephalopathy

dysfunction. [centerwatch.com]

Diagnosis is based on reported neurological deficits combined with laboratory abnormalities showing severe liver dysfunction. [bestpractice.bmj.com]

CONCLUSIONS: PPIs are associated with a higher risk of HE among patients with chronic and acute liver dysfunction. [ncbi.nlm.nih.gov]

Cardiac Cirrhosis

Liver dysfunction can become a serious medical issue, as an impaired liver is less capable of metabolizing chemical compounds. [wisegeek.com]

Usual management of liver cirrhosis as indicated in the setting of liver dysfunction irrespective of the etiology, such as beta-blockers to reduce portal hypertension, diuretics [ncbi.nlm.nih.gov]

liver dysfunction. [verywell.com]

Hepatorenal Syndrome

Severe liver dysfunction may lead to impairment of renal function without an underlying renal pathology. [ncbi.nlm.nih.gov]

A complication of end-stage liver disease which occurs in patients who have chronic liver dysfunction with cirrhosis and ascites and also in acute liver failure. [patient.info]

Hepatopulmonary Syndrome

BACKGROUND: Hepatopulmonary syndrome (HPS) is defined by liver dysfunction, intrapulmonary vascular dilatations, and impaired oxygenation. [ncbi.nlm.nih.gov]

[…] evidence of IPVDs, but no significant oxygenation abnormality (AaDO2≤20mmHg, and PaO2>70mmHg)] (22 patients) and those with liver dysfunction only (liver dysfunction and/ [journals.plos.org]

Hepatopulmonary syndrome is an uncommon complication of nonacute liver failure, and in rare cases, hypoxia may be the presenting sign of liver dysfunction. [ncbi.nlm.nih.gov]

Idiosyncratic Drug-Induced Liver Injury

A 65-year-old woman receiving hemodialysis due to diabetic nephropathy presented with slowly progressive liver dysfunction. [care.diabetesjournals.org]

In individuals with suspected DILI, especially when liver biochemistries are rising rapidly or there is evidence of liver dysfunction, suspected agent(s) should be promptly [utahgastroblog.com]

It can manifest as an asymptomatic elevation in liver chemistries or symptomatically with liver dysfunction. [clinicaladvisor.com]

Alstrom Syndrome

Prognosis The prognosis will depend on the progression of glucose intolerance, cardiomyopathy, renal dysfunction and liver impairment. [patient.info]

Serial examinations showed liver dysfunction and pancreatitis. [ncbi.nlm.nih.gov]

Liver dysfunction. Visual impairment. Deafness. Heart failure and other features of cardiomyopathy, eg cardiac arrhythmias. Hypothyroidism. [patient.info]

Alpers Syndrome

Liver dysfunction constitutes a late manifestation. [ncbi.nlm.nih.gov]

The process of liver failure may worsen as a result of the disease itself, and it may worsen with the antiepileptic drug valproic acid, a catalyst for liver dysfunction in [consultant360.com]

dysfunction and failure (Huttenlocher et al., 1976). [theses.ncl.ac.uk]

Acute Liver Failure

In addition to severe liver dysfunction, some of these individuals also suffered from other comorbidities including cardiomyopathy, neurologic phenotypes and gastrointestinal [ncbi.nlm.nih.gov]

She developed postoperative liver dysfunction, most likely owing to the persistence of the diseased native liver, ultimately leading to an orthotopic retransplantation. [ncbi.nlm.nih.gov]

No other cause for seizures and liver dysfunction were found. [ncbi.nlm.nih.gov]

Mitochondrial DNA Depletion Syndrome

Hepatocerebral MDS, caused by mutations in DGUOK, MPV17, POLG, or C10orf2, commonly have an early-onset liver dysfunction and neurological involvement. [ncbi.nlm.nih.gov]

Alpers syndrome is characterised by intractable epilepsy and liver dysfunction, but either problem can present in isolation. [adc.bmj.com]

Onset is during infancy, and clinical features include liver dysfunction and failure, developmental delay, failure to thrive, lactic acidosis and muscle weakness. [sema4genomics.com]

Citrullinemia Type 2

NICCD is characterized by suppression of the bile flow, hepatic fibrosis, low birth weight, growth retardation, hypoproteinemia, variable liver dysfunction. [abcam.com]

Chronic liver disease can reduce the number of liver cells and lead to liver dysfunction, causing reduced insulin inactivation. [journals.lww.com]

The outcome of the disease is fatal liver dysfunction and hepatic encephalopathy in the first days of life. [hpbonline.org]

Tyrosinemia

This transient elevation is a pattern associated with liver immaturity or dysfunction. [rh.perkinelmer.com]

Abstract Clinically, Hereditary Tyrosinemia type I (HTI) is especially characterized by severe liver dysfunction in early life. [ncbi.nlm.nih.gov]

HTI is characterized by progressive liver dysfunction with nodular cirrhosis often leading to hepatocellular carcinoma. [ncbi.nlm.nih.gov]

Mitochondrial Neurogastrointestinal Encephalomyopathy

Onset is during infancy, and clinical features include liver dysfunction and failure, developmental delay, failure to thrive, lactic acidosis and muscle weakness. [sema4genomics.com]

There are different types of DNA depletion syndromes, which can lead to muscle weakness before the children reach the age of 2, neurological problems and liver dysfunction [ibtimes.co.uk]

Additionally, although physical signs of chronic liver dysfunction may not be present, many people suffer liver impairment leading to liver failure. [8] [9] In MDDS associated [en.wikipedia.org]

Glycogen Storage Disease Type 4

Liver dysfunction, myopathy, and hypotonia in childhood Childhood neuromuscular subtype. [ncbi.nlm.nih.gov]

[…] function Liver dysfunction 0001410 Hepatitis Liver inflammation 0012115 Muscular hypotonia Low or weak muscle tone 0001252 5%-29% of people have these symptoms Hypertrophic [rarediseases.info.nih.gov]

Nota bene: Liver biopsy may be needed to determine the cause of progressive liver dysfunction. [humpath.com]