Recurrent Bacterial Infection: Causes & Reasons

Possible Causes for Recurrent Bacterial Infection

bacterial infections (e.g. otitis media, pneumonia, sinusitis, urinary tract infections, abscesses of skin and/or liver) and increased promyelocytes in the bone marrow. [ebi.ac.uk]

bacterial infections Bacterial infections, recurrent Frequent bacterial infections Increased susceptibility to bacterial infections Recurrent major bacterial infections [ [rarediseases.info.nih.gov]

[…] rare, severe, congenital neutropenia disorder characterized by a lack of mature neutrophils (absolute neutrophil counts less than 500 cells/mm3) associated with frequent, recurrent [ebi.ac.uk]

Common Variable Immunodeficiency

It results in recurrent bacterial infections. [icd9data.com]

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized by hypogammaglobulinaemia, T-cell abnormalities and recurrent bacterial infections. [ncbi.nlm.nih.gov]

It is characterized by recurrent bacterial infections, and occurrence of autoimmune and neoplastic diseases is also frequent; there is also a high prevalence of gastrointestinal [ncbi.nlm.nih.gov]

Complement Factor I Deficiency

[…] or inflammation Autosomal recessive inheritance Clinical features Recurrent nonsuppurative bacterial infections (e.g., skin and mucosal), impaired wound healing Omphalitis [amboss.com]

Bacterial Infections -Primary -Complement deficiencies -Factor H and I Hematologic/Lymphoproliferative Disorders -Secondary -Hodgkin`s disease/Lymphomas -Leukemia -Myeloma [quizlet.com]

The development of severe, persistent recurrent bacterial infection is a better indicator. [patient.info]

Complement Component 3 Deficiency

Recurrent bacterial infections MedGen UID: 893153 • Concept ID: C4020846 • Finding Increased susceptibility to bacterial infections, as manifested by recurrent episodes of [ncbi.nlm.nih.gov]

bacterial infections ; Renal insufficiency ; Systemic lupus erythematosus Associated Genes C3 (Withdrawn symbols: ARMD9, C3a, C3b, CPAMD1 ) Mouse Orthologs C3 (Withdrawn [mousephenotype.org]

People with complement component 8 deficiency have a significantly increased risk of recurrent bacterial infections, particularly by a bacterium called Neisseria meningitidis [icdlist.com]

Agammaglobulinemia

XLA develop recurrent bacterial infections, particularly otitis, sinusitis and pneumonia, in the first two years of life. [esid.org]

Recurrent bacterial infections of the skin, lungs and the gastrointestinal tract appearing in infancy are the main clinical presentation. [symptoma.com]

This syndrome is featured by (a) a history of recurrent bacterial infections, (b) absence of acquired antibodies, (c) lack of isohemagglutins, (d) extremely low to absent [annals.org]

X-Linked Agammaglobulinemia Type 1

XLA develop recurrent bacterial infections, particularly otitis, sinusitis and pneumonia, in the first two years of life. [esid.org]

The diagnosis was delayed due to near-normal levels of serum immunoglobulins, although he presented with severe and recurrent bacterial infections since the age of 1year. [ncbi.nlm.nih.gov]

Patients typically become symptomatic during infancy or early childhood and develop recurrent bacterial infections. [ncbi.nlm.nih.gov]

Complement 3 Deficiency

Severe recurrent bacterial infections occur in patients with homozygous C3 deficiency and in those patients with low levels of C3 secondary to the absence of C3b activator [mayomedicallaboratories.com]

bacterial infections Deficiency of C5, C9, factor B, factor D, or properdin: Susceptibility to neisserial infections Mutations in the genes for factor B, factor H, factor [merckmanuals.com]

At least 17 mutations in the C3 gene have been found to cause C3 deficiency, a rare condition characterized by recurrent bacterial infections beginning in childhood. [ghr.nlm.nih.gov]

Kenny-Caffey Syndrome Type 1

A similar syndrome with the additional features of osteosclerosis and recurrent bacterial infections has been classified as autosomal recessive Kenny-Caffey syndrome (AR-KCS [scienceopen.com]

A similar syndrome with the additional features of osteosclerosis and recurrent bacterial infections is the autosomal recessive Kenny-Caffey syndrome. [flybase.org]

bacterial infections ; Seizures ; Short foot ; Short palm ; Slender long bone ; Small hand ; Tetany ; Thin clavicles ; Thin ribs Associated Genes TBCE (Withdrawn symbols: [mousephenotype.org]

Chronic Granulomatous Disease

Consequently, these patients develop recurrent bacterial infections by Staphylococcus aureus, Chromobacterium violaceum, Nocardia species, Serratia maresecens, legionella [ijdvl.com]

Hence, these individuals have recurrent bacterial infections. [mybiosource.com]

Chronic granulomatous disease (CGD) is a life threatening inherited disorder with varied clinical presentations often characterized by recurrent bacterial and fungal infections [ncbi.nlm.nih.gov]

Hyper-IgE Syndrome

PURPOSE: Autosomal Dominant Hyper IgE Recurrent Infection Syndrome (AD-HIES) is caused by mutations in STAT3 and characterized by eczema, recurrent bacterial infections, and [ncbi.nlm.nih.gov]

Purpose Autosomal Dominant Hyper IgE Recurrent Infection Syndrome (AD-HIES) is caused by mutations in STAT3 and characterized by eczema, recurrent bacterial infections, and [infona.pl]

Lancet. 1966; 1: 1013-1015 Hill HR Quie PG Raised serum IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. [jaad.org]

Selective IgA Immunodeficiency

[…] or inflammation Clinical features Recurrent nonsuppurative bacterial infections (e.g., skin and mucosal), impaired wound healing Omphalitis in the newborn (delayed separation [amboss.com]

The development of severe, persistent recurrent bacterial infection is a better indicator. [patient.info]

Recurrent bacterial sinus and pulmonary infections are the hallmark of antibody primary immunodeficiencies. [aafp.org]

Sanjad-Sakati Syndrome

bacterial infections. [ijcpjournal.org]

A similar syndrome with the additional features of osteosclerosis and recurrent bacterial infections has been classified as autosomal recessive Kenny-Caffey syndrome (AR-KCS [scienceopen.com]

244460), which shares similar phenotypic and genotypic features, but additionally presents with osteosclerosis, medullary stenosis of the long bones, normal intelligence, and recurrent [ijcpjournal.org]

Leukocyte Adhesion Deficiency Type 3

Possible diagnosis: patients with important leucocytosis >25,000cells/mm3 and one of the following: - Recurrent bacterial infections. - Deep-seated and severe infection. - [elsevier.es]

Probable diagnosis: patients with diminished CD18 expression in neutrophils (<5% of normal), and all of the following: - Recurrent bacterial or fungal infections. - Leucocytosis [elsevier.es]

bacterial infections mainly of the skin and mucosal membranes, leucocytosis, periodontitis, the absence of pus and poor wound healing.1,7–9 The severity of the infectious [elsevier.es]

Hyper-IgM Syndrome Type 2

Recurrent bacterial infections MedGen UID: 334943 •Concept ID: C1844383 • Finding Increased susceptibility to bacterial infections, as manifested by recurrent episodes of [ncbi.nlm.nih.gov]

bacterial sinopulmonary and gastrointestinal infections, with frequent lymphoid hyperplasia (peripheral lymphadenopathy, tonsillar hypertrophy), with no increased susceptibility [orpha.net]

The most common symptoms of hyper IgM syndrome include: Increased susceptibility to bacterial and viral infections, specifically recurrent upper and lower respiratory tract [chop.edu]

X-linked Severe Congenital Neutropenia

Individuals with XLN have a persistent neutropenia due to a promyelocyte/myelocytic maturation arrest and recurrent bacterial infections. [genedx.com]

Age Patients are diagnosed shortly after birth with recurrent bacterial infections within the first few months of life. [emedicine.medscape.com]

Hyper-IgM Syndrome Type 5

bacterial infections Abnormality of the respiratory system Recurrent upper and lower respiratory tract infections IMPORTANT NOTE: NIH does not independently verify information [ncbi.nlm.nih.gov]

bacterial infections, Recurrent upper and lower respiratory tract infections *This computer-generated image is for illustration purposes only How does someone get tested [fdna.health]

Common Variable Immunodeficiency Type 4

It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development. [icd10data.com]

Although, most individuals with CVID present first with recurrent bacterial infections, in about 20% of cases the first manifestation of the immune defect is a finding of [primaryimmune.org]

The diagnosis is usually made between the ages of 20 and 40 years but in 20% of cases it is diagnosed before the age of 20.[2] CVID presents often with recurrent bacterial [healthunlocked.com]

Hyper-IgM Syndrome

Symptoms of hyper IgM syndrome include recurrent bacterial infections and pneumonia infections in newborn infants. [stanfordchildrens.org]

Patients with these syndromes typically have recurrent bacterial infections and often have lymphoid hyperplasia. [genome.jp]

[…] sclerosing cholangitis and liver cirrhosis The dermatological signs include frequent and recurrent bacterial and fungal skin infections and oral ulcers. [dermnetnz.org]

Chronic Granulomatous Disease due to NCF2 Deficiency

Recurrent Staphylococcus aureus infections ; Recurrent bacterial skin infections ; Recurrent pneumonia ; Splenomegaly Associated Genes NCF2 (Withdrawn symbols: NOXA2, p67phox [mousephenotype.org]

MYD88 DEFICIENCY; MYD88D Is also known as pyogenic bacterial infections, recurrent, due to myd88 deficiency, recurrent pyogenic bacterial infections due to myd88 deficiency [mendelian.co]

bacterial infections Serratia marcescens infectious lymphadenitis (infectious adenitis) bacteria lymphadenitis adenitis S. aureus mycobacteria pulmonary infection due to [humpath.com]

Autosomal Recessive Agammaglobulinemia Type 3

People affected by this condition generally begin developing frequent and recurrent bacterial infections from about 6 months of age. [rarediseases.info.nih.gov]

bacterial infections. [mayomedicallaboratories.com]

The development of severe, persistent recurrent bacterial infection is a better indicator. [patient.info]

Hermansky-Pudlak Syndrome Type 2

[…] abscess formation 0002722 Recurrent bacterial infections Bacterial infections, recurrent Frequent bacterial infections Increased susceptibility to bacterial infections Recurrent [rarediseases.info.nih.gov]

[…] major bacterial infections [ more ] 0002718 Recurrent otitis media Recurrent middle ear infection 0000403 Recurrent pneumonia 0006532 Reduced natural killer cell activity [rarediseases.info.nih.gov]

[…] sensitivity of the eyes to light Light hypersensitivity [ more ] 0000613 Posteriorly rotated ears Ears rotated toward back of head 0000358 Prolonged bleeding time 0003010 Recurrent [rarediseases.info.nih.gov]

Alpha-Mannosidosis

Frequent clinical findings include recurrent bacterial infections, deafness, hepatomegaly, and lenticular or corneal opacities. [emedicine.medscape.com]

[…] midface Midface deficiency Underdevelopment of midface [ more ] 0011800 Nystagmus Involuntary, rapid, rhythmic eye movements 0000639 Pectus carinatum Pigeon chest 0000768 Recurrent [rarediseases.info.nih.gov]

Autosomal Recessive Agammaglobulinemia Type 4

bacterial infections, conjunctivitis, sinopulmonary infections, diarrhea, skin infections 3-6/1,000,000 Early onset Bleeding disorder platelet type ACTN1, GFI1B, P2RY12 Mild [centogene.com]

People affected by this condition generally begin developing frequent and recurrent bacterial infections from about 6 months of age. [rarediseases.info.nih.gov]

bacterial infections. [mayomedicallaboratories.com]

Severe Combined Immunodeficiency

CONCLUSIONS: Infants with SCID appear normal at birth but later present with failure to thrive and/or recurrent fungal, viral, and bacterial infections. [ncbi.nlm.nih.gov]

A baby with SCID will have recurrent bacterial, viral, or fungal infections that are much more serious and less responsive to treatment than would normally be expected. [rchsd.org]

bacterial, viral, fungal, and protozoal infections chronic diarrhea Physical exam may see thrush in mouth and diaper area eczematous dermatitis erythroderma (> 90% body surface [medbullets.com]

Primary Antibody Deficiency Disorder

If patients are symptomatic, they present with recurrent sinopulmonary bacterial infections. [ncbi.nlm.nih.gov]

bacterial infections. [ncbi.nlm.nih.gov]

• Failure to thrive from early infancy • Recurrent pyogenic infections • Unusual infections or unusually severe course of infections • Recurrent infections with the same [ncbi.nlm.nih.gov]

Griscelli Syndrome Type 2

bacterial infections ; Reduced delayed hypersensitivity ; Seizures ; Silver-gray hair ; Spasticity Associated Genes RAB27A (Withdrawn symbols: GS2, HsT18676, RAB27, RAM ) [mousephenotype.org]

(eg, Epstein-Barr virus, hepatitis A virus, herpes virus 6) or sometimes a bacterial infection. [emedicine.medscape.com]

Complement Factor D Deficiency

Related phenotypes are recurrent bacterial infections and complement deficiency UniProtKB/Swiss-Prot : 75 Complement factor D deficiency: An immunologic disorder characterized [malacards.org]

People with complement component 8 deficiency have a significantly increased risk of recurrent bacterial infections, particularly by a bacterium called Neisseria meningitidis [icdlist.com]

[…] or inflammation Autosomal recessive inheritance Clinical features Recurrent nonsuppurative bacterial infections (e.g., skin and mucosal), impaired wound healing Omphalitis [amboss.com]

Complement Deficiency Syndrome

People with complement component 8 deficiency have a significantly increased risk of recurrent bacterial infections, particularly by a bacterium called Neisseria meningitidis [icdlist.com]

People with complement deficiencies are susceptible only to recurrent bacterial infections. B. People with any kind of PIDD are susceptible to bacterial infections C. [brainscape.com]

People with complement component 2 deficiency have a significantly increased risk of recurrent bacterial infections, specifically of the lungs (pneumonia), the membrane covering [ghr.nlm.nih.gov]

Autosomal Agammaglobulinemia

bacterial infections in affected males. [arupconsult.com]

People affected by this condition generally begin developing frequent and recurrent bacterial infections from about 6 months of age. [rarediseases.info.nih.gov]

This includes recurrent bacterial infections occurring at an early age, small or absent tonsils and lymph nodes on physical examination and very low levels of immunoglobulins [invitae.com]

Congenital Agammaglobulinemia

Symptoms of XLA are recurrent bacterial infections especially in the ears, sinuses and lungs. [pediatriconcall.com]

bacterial infections in affected males. [arupconsult.com]

In 1952, Bruton [1] described the first case of XLA in a male patient with recurrent bacterial infections. [wjpch.com]