Respiratory Muscle Weakness: Causes & Reasons

Possible Causes for Respiratory Muscle Weakness

Respiratory muscle weakness first manifests as sleep-disordered breathing (SDB). [clinicaltrials.gov]

In addition, respiratory muscle weakness is often observed after stroke, contributing to exercise intolerance and a higher risk of poor outcome. [pnmedical.com]

Respiratory muscle weakness contributes to sleep-disordered breathing. [gbppa.org]

Late-Onset Pompe Disease

weakness, respiratory muscle dysfunction, and cardiomyopathy (in infants only). [ncbi.nlm.nih.gov]

Skeletal muscle involvement LOPD is characterized by progressive muscle weakness with respiratory insufficiency that may present at any age greater than 12 months, leading [ncbi.nlm.nih.gov]

The association of respiratory insufficiency and degree of weakness or muscle involvement has been previously noted to have poor direct correlation.7,8 Muscle biopsy can be [ncbi.nlm.nih.gov]

Pompe Disease

Aspiration pneumonia; weakness of ventilatory muscles increases the risk of pneumonia. The adult form manifests with dystrophy and respiratory muscle weakness. [patient.info]

Dyspnea secondary to diaphragm or respiratory muscle weakness may also be observed. [symptoma.com]

Some patients have presented with pulmonary (lung) insufficiency due to respiratory muscle weakness. [agsdus.org]

Spinal Muscular Atrophy Type 1

Most of these patients develop foot deformities, scoliosis, and respiratory muscle weakness. [mda.org]

They have extremely weak muscle tone (hypotonia) at birth. Their respiratory muscles are very weak and they often do not survive past infancy due to respiratory failure. [ghr.nlm.nih.gov]

Respiratory muscle weakness is generally the cause of death in children with type 1 or 2 SMA. Your child may need to be monitored for respiratory distress. [healthline.com]

Congenital Merosin-Positive Muscular Dystrophy

[…] tissue disease 0003198 Neck muscle weakness Floppy neck 0000467 Neonatal hypotonia Low muscle tone, in neonatal onset 0001319 Proximal muscle weakness Weakness in muscles [rarediseases.info.nih.gov]

CMD with muscle hypertrophy and respiratory failure. (14)Ullrich congenital muscular dystrophy – present at birth is weakness, poor muscle tone, will have some deformity [mobilephysiotherapyclinic.in]

muscle weakness—can prolong life expectancy. 18 A possible limitation of this study was the fact that histopathological and genetic testing was only performed for a few patients [ncbi.nlm.nih.gov]

Distal Spinal Muscular Atrophy Type 4

Etiology Pathophysiology Clinical features The most common causes of death among patients with SMA are respiratory insufficiency (due to respiratory muscle weakness ) and [amboss.com]

Respiratory dysfunction Progressive respiratory dysfunction may resulted due to respiratory muscle weakness due to loss of motor neurons in spinal cord.It may also causes [explainmedicine.com]

Symptoms vary in severity and may include muscle weakness and atrophy, fasciculations, emotional lability, and respiratory muscle weakness. [msdmanuals.com]

Spinal Muscular Atrophy

They have extremely weak muscle tone (hypotonia) at birth. Their respiratory muscles are very weak and they often do not survive past infancy due to respiratory failure. [ghr.nlm.nih.gov]

Progressive respiratory muscle weakness with bulbar involvement is the main cause of morbidity and mortality in type I and severe type II spinal muscular atrophy. [ncbi.nlm.nih.gov]

Respiratory muscle weakness frequently leads to pneumonia, which can be life threatening. [nationwidechildrens.org]

Congenital Muscular Dystrophy Type 1A

weakness and muscle wasting. [rarediseases.info.nih.gov]

Weak respiratory muscles make breathing difficult, and a number of children suffer from complications in the form of lung inflammation. [mediconvillage.se]

weakness, and muscle wasting (Tables 18.1 and 18.2). [link.springer.com]

Amyotrophic Lateral Sclerosis

Symptoms vary in severity and may include muscle weakness and atrophy, fasciculations, emotional lability, and respiratory muscle weakness. [msdmanuals.com]

Respiratory muscle weakness and failure is a common complication late in the course of disease. [ncbi.nlm.nih.gov]

Weekly data downloads showed that disease progression was associated with increased respiratory muscle weakness, decreased spontaneous breathing, and increased use of non-invasive [ncbi.nlm.nih.gov]

Botulism

Low respiratory rate The fatal outcome of muscle paralysis in botulism is respiratory muscle weakness. Once started, it progresses rapidly. [medicaljoyworks.com]

Common symptoms include a very flaccid paralysis of the arms and/or legs, difficulty breathing because of respiratory muscle weakness and blurred vision. [foxnews.com]

[…] or weakness of motor and autonomic nerves Respiratory muscle weakness may be subtle or progressive, advancing rapidly to respiratory failure The autonomic nervous system [emedicine.medscape.com]

Becker Muscular Dystrophy

Our cases became unable to walk in their teens, and were introduced to mechanical ventilation due to respiratory muscle weakness in their twenties and thirties. [ncbi.nlm.nih.gov]

Other complications Respiratory muscle weakness: Depending on the clinical severity of muscle weakness, this is a possible complication. [patient.info]

[…] expiratory muscle weakness, to assess selective weakness of specific respiratory muscle groups, and/or to delineate abnormalities in lung and chest wall mechanics. [clinicaladvisor.com]

Duchenne Muscular Dystrophy

Patients become wheelchair bound and develop respiratory muscle weakness. [stanfordhealthcare.org]

In this context, the most frequent respiratory complication is nocturnal and daytime hypoventilation related to respiratory muscle weakness. [ncbi.nlm.nih.gov]

Some patients may need assisted ventilation to treat respiratory muscle weakness and a pacemaker for cardiac abnormalities. [ninds.nih.gov]

Oculo-Pharyngo-Distal Myopathy

Differential diagnosis and investigation of respiratory muscle weakness according to clinical presentation Patients presenting with respiratory muscle weakness will typically [dovepress.com]

Importantly, a considerable proportion of patients developed respiratory muscle weakness while still ambulant. [ncbi.nlm.nih.gov]

Many people have respiratory problems due to respiratory muscle weakness. [rarediseases.info.nih.gov]

Polymyositis

Pulmonary involvement in polymyositis includes respiratory muscle weakness, aspiration pneumonia, interstitial lung disease, infection and drug-induced pneumonia. [ncbi.nlm.nih.gov]

Dysphagia and neck flexor weakness can develop along with respiratory muscle weakness as the disease progresses. [ncbi.nlm.nih.gov]

In rare cases individuals with severe and progressive muscle weakness will develop respiratory failure or pneumonia. [ninds.nih.gov]

Dermatomyositis

weakness, dysphonia, dysphagia Less common: respiratory muscle weakness, visual changes, abdominal pain Systemic complications/association: Aspiration pneumonia secondary [physio-pedia.com]

dysphonia, dysphagia Less common: respiratory muscle weakness, visual changes, abdominal pain Systemic complications/association: Cardiomyopathy Cardiac conduction defects [physio-pedia.com]

[…] lung disease  10% of cases  respiratory failure may result from diaphragmatic and chest muscle weakness  can result in rapid respiratory failure and death  Esophageal [docsity.com]

Bulbar Poliomyelitis

Respiratory muscle weakness contributes to sleep-disordered breathing. [post-polio.org]

Pure spinal poliomyelitis with respiratory insufficiency involves tightness, weakness, or paralysis of the respiratory muscles (chiefly the diaphragm and intercostals) without [easypediatrics.com]

The main clinical manifestations of poliomyelitis are weakness, decreased muscle tone, and hyporeflexia. [amboss.com]

Myotonic Dystrophy

Children with congenital-onset DM1, once they survive the crucial neonatal period of respiratory muscle weakness with the help of assisted ventilation, usually show improvements [mda.org]

Breathing and swallowing muscle weakness Respiratory muscle weakness does not appear to be a common feature of DM2. [mda.org]

Congenital myotonic dystrophy is a severe form of this disorder, characterized by neonatal muscle hypotonia, feeding difficulties, respiratory muscle weakness, and an increased [icd10data.com]

Hypokalemia

Additionally, patients may experience respiratory muscle weakness that may lead to respiratory failure, as well as vomiting and diarrhea that will potentiate further potassium [emra.org]

Paraesthesiae Decreased reflexes Ascending paralysis Hypokalaemia Defined as potassium Signs and symptoms Generalised muscle weakness Respiratory depression Ascending paralysis [armandoh.org]

Eleven patients had a history of recurring muscle weakness. All patients had quadraparesis (muscle weakness in all four limbs); in 10 patients the weakness was severe. [acutecaretesting.org]

Lambert-Eaton Syndrome

Respiratory difficulty The respiratory muscle weakness and consequent respiratory paralysis may occur later in the cause, but initial presentation with respiratory paralysis [medicaljoyworks.com]

However, because most patients with MG are on immunosuppressive or immunomodulatory therapies and may also have respiratory muscle weakness, there is a theoretical concern [wfneurology.org]

Limb and girdle muscles are predominantly involved, respiratory muscle weakness is common, and although respiratory failure is infrequent, it may be the initial presenting [pulmonologyadvisor.com]

Familial Periodic Paralysis

Each type of periodic paralysis syndrome has characteristic symptoms and causes, for example, irregular heartbeats, weakness of the respiratory muscles, and muscle weakness [medicinenet.com]

Following administration of general anesthesia, the affected individual may develop respiratory distress in the recovery room resulting from weakness of respiratory muscles [ncbi.nlm.nih.gov]

muscles. [1] The myopathic form, a fixed muscle weakness, slowly progresses and presents as exercise intolerance predominantly of the lower limbs. [ijaweb.org]

Carbamate Poisoning

Occurs 24-96 hours after exposure Bulbar, respiratory, and proximal muscle weakness are prominent features. Generally resolves completely in 1-3 weeks. [authorstream.com]

Miosis (73%), excessive salivation (70%), muscle weakness (68%), and lethargy (54%) were the most common abnormal signs; 49% and 22% of patients had tachycardia and seizures [utexas.influuent.utsystem.edu]

Clinical Features (Acute Toxicity): Clinical Features (Acute Toxicity) Respiratory insufficiency can result from muscle weakness, decreased central drive, increased secretions [authorstream.com]

Mussel Poisoning

[…] distress; drowsiness; muscle weakness; incoherent speech Yes. [myfwc.com]

Nausea, vomiting, and abdominal cramps then develop, followed by muscle weakness. [merckmanuals.com]

Respiratory difficulty, salivation, temporary blindness, nausea and vomiting may also occur. [inspection.gc.ca]

Chronic Obstructive Pulmonary Disease

Age, respiratory muscle weakness, hypercapnia, hypoxia, malnutrition, treatment with corticosteroids or other agents, haemodynamic instability and activity limits due to respiratory [doi.org]

Respiratory muscle weakness Receptors. [dx.doi.org]

Ethical problems about the treatment of acute exacerbation of end-stage COPD are increasingly topical, especially in respiratory units and the ICU. [doi.org]

Pulmonary Fibrosis

Neuromuscular disorders occur as the respiratory muscle weakness progresses. [web.archive.org]

Individuals with respiratory illnesses tend to have weak diaphragms because of difficulty breathing. Lie down on your back with your knees bent. [livestrong.com]

The cause of respiratory failure is often multifactorial and is secondary to spinal deformity, muscle weakness, disordered ventilatory control, sleep disordered breathing, [web.archive.org]

Thymidine Kinase 2 Deficiency

Affected individuals typically develop severe and progressive muscle weakness involving respiratory muscles. [ncbi.nlm.nih.gov]

Speech Therapy Muscle weakness in the throat may make talking or swallowing difficult. Speech therapy can help strengthen the muscles or work around the weakness. [neurosciences.uvahealth.com]

They developed normally until 12 to 16 months of age, when walking was delayed, limb muscles became progressively weak and hypotonic, and death from respiratory failure occurred [pediatricneurologybriefs.com]

Spinal Paralytic Poliomyelitis

The researchers saw this in their study—two siblings tested positive for the enterovirus, but one developed muscle weakness while the other only had respiratory symptoms. [wired.com]

weakness, paralysis and respiratory paralysis Etiology Viral, in particular poliovirus, but also coxsackie A7, enterovirus 71, and others Clinical If extreme, asymmetric [medical-dictionary.thefreedictionary.com]

If the spinal cord is affected closer to the brain or if the lower part of the brain called the brain stem is affected there may be severe paralysis of the respiratory muscles [news-medical.net]

Congenital Myasthenic Syndrome Type 10

The sickest patients have severe ocular, bulbar and respiratory muscle weakness from birth and survive only with respiratory support and gavage feeding. [rarediseases.org]

Complications Aspiration pneumonia due to throat muscle weakness. Acute respiratory failure during an exacerbation. [patient.info]

The common features of CMS are an exercise induced weakness of skeletal muscle. At birth, they may present with hypotonia, respiratory distress or joint contractures. [annalsofian.org]

Acute Respiratory Distress Syndrome

That f/V T had a strong, inverse relationship to peak negative esophageal pressure also may reflect the influence of muscle weakness. acute lung injury acute respiratory distress [rc.rcjournal.com]

A recovering patient’s quality of life may be severely adversely affected by permanent damage to the lungs, respiratory problems, renal dysfunction, muscle weakness and depression [faron.com]

CONCLUSION: The characteristic rapid shallow breathing pattern in patients with ARDS/ALI occurs in the context of markedly diminished compliance, elevated respiratory drive [rc.rcjournal.com]

Amyotrophic Lateral Sclerosis Type 21

Death usually results from respiratory failure, due to denervation weakness in respiratory muscles. [cochranelibrary.com]

Measures of respiratory muscle strength (for example, forced vital capacity, sniff nasal inspiratory pressure) are useful in monitoring the progression of respiratory muscle [cochranelibrary.com]

weakness, but no single test of respiratory function can be used to reliably predict the onset of respiratory failure. [cochranelibrary.com]

Nemaline Myopathy Type 2

Symptoms - Nemaline Myopathy 2 Breathing problems Reduced muscle tone at birth Limb weakness Trunk weakness Weak face muscles Respiratory muscle weakness Weak neck muscles [checkorphan.org]

[…] absent deep tendon reflexes Feeding and swallowing difficulties Breathing difficulties and recurrent respiratory infections due to respiratory muscles weakness Joint contractures [centogene.com]

Most patients have respiratory insufficiency due to muscle weakness. Other common features include myopathic facies, high-arched palate, and scoliosis. [diseaseinfosearch.org]