Thrombophilia: Causes & Reasons

Possible Causes for Thrombophilia

Treating thrombophilia Many people with thrombophilia won't need treatment. [nhs.uk]

Applicable To Antithrombin III deficiency Hypercoagulable state NOS Primary hypercoagulable state NEC Primary thrombophilia NEC Protein C deficiency Protein S deficiency Thrombophilia [icd10data.com]

KEYWORDS: Breakpoint analyses; Copy number mutation; Genomic architecture; Inherited thrombophilia; PROS1 [ncbi.nlm.nih.gov]

Anticardiolipin Antibody Syndrome

D68.51 Activated protein C resistance D68.52 Prothrombin gene mutation D68.59 Other primary thrombophilia D68.6 Other thrombophilia D68.61 Antiphospholipid syndrome D68.62 [icd10data.com]

Thrombophilias. March of Dimes Pregnancy Complications [On-line information]. [labtestsonline.org]

Thrombophilias. March of Dimes. Available online at http://www.marchofdimes.com/pregnancy/thrombophillias.aspx. Accessed June 2014. Belilos, E. [labtestsonline.it]

Paroxysmal Nocturnal Hemoglobinuria

RESULTS: The screening tests for thrombophilia were not successful. However, elevated LDH was detected, leading to the diagnosis of PNH. [ncbi.nlm.nih.gov]

Inherited thrombophilias were rare (three confirmed cases). Therefore, PNH does not appear to play a role in the development of RVO. [ncbi.nlm.nih.gov]

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, nonmalignant disorder of hematopoietic stem cells characterized by hemolysis, diminished hematopoiesis, and thrombophilia [ncbi.nlm.nih.gov]

Protein C Deficiency

Recently, several studies have revealed an outline of inherited thrombophilias in Japanese children. [ncbi.nlm.nih.gov]

Specific types of inherited thrombophilias 1. [dx.doi.org]

Factor V Leiden (G1691A) and factor II mutation (G20210A) are the leading causes of inherited thrombophilias in Caucasians, but are not found in Asian ancestries. [ncbi.nlm.nih.gov]

Factor II Mutation

Prothrombin thrombophilia is the second most common inherited form of thrombophilia after factor V Leiden thrombophilia. [ghr.nlm.nih.gov]

Family Member Testing for Thrombophilia February 2nd, 2011 | Clotting disorder - thrombophilia, Factor V Leiden, Inherited (genetic), Protein C deficiency, Protein S deficiency [patientblog.clotconnect.org]

Whereas maternal thrombophilia has a subsequently higher incidence, both maternal and fetal thrombophilia can lead to adverse maternal and fetal events. [womenshealthsection.com]

Hereditary Factor I Deficiency

Inherited thrombophilia: Diagnostic approach. [ijhonline.org]

Specific types of inherited thrombophilias 1. [thrombosisjournal.biomedcentral.com]

CHAPTER 127 HEREDITARY THROMBOPHILIA Williams Hematology CHAPTER 127 HEREDITARY THROMBOPHILIA SCOTT H. GOODNIGHT JOHN H. [medtextfree.wordpress.com]

Hereditary Antithrombin Deficiency

[Olav Egeberg--hereditary antithrombin deficiency and thrombophilia]. [unboundmedicine.com]

Specific types of inherited thrombophilias 1. [thrombosisjournal.biomedcentral.com]

Hereditary Protein C Deficiency

Treating thrombophilia Many people with thrombophilia won't need treatment. [nhs.uk]

Bertina A stepwise approach to thrombophilia testing. 1. [slideshare.net]

Occult Malignancy

[…] be tested for inherited thrombophilia. [the-hospitalist.org]

Seventeen patients were excluded because of congenital or acquired thrombophilia, known cancer, estrogen use, inability to confirm VTE diagnosis, or missing data. [ncbi.nlm.nih.gov]

Unprovoked VTE was defined as VTE in the absence of active cancer, hereditary or acquired thrombophilia, current pregnancy, previous unprovoked VTE or a temporary prespidosing [bcs.com]

Essential Thrombocythemia

Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera. [wjgnet.com]

/diagnosis Thrombophilia/drug therapy Thrombophilia/etiology Substances Quinazolines Receptors, Thrombopoietin MPL protein, human JAK2 protein, human Janus Kinase 2 anagrelide [ncbi.nlm.nih.gov]

This platelet-mediated thrombotic disease (platelet thrombophilia) in the end-arterial circulation of thrombocythemia (ET and PV) patients, first described by Michiels et [wjgnet.com]

Puerperium

Familial thrombophilia Thromboembolism is a multifactorial disease, in many cases developing as a result of a thrombotic tendency (a thrombophilia) interacting with other [mja.com.au]

Genetic polymorphisms associated with thrombophilia such as factor V Leiden, prothrombin G20210A, MTHFR C677T, ACE and PIA1/A2 may be the cause of the hypercoagulability that [ncbi.nlm.nih.gov]

Four patients who had DVT during a normal course of pregnancy had severe thrombophilia: antiphospholipid antibody syndrome, a history of thrombosis and antithrombin (AT) deficiency [ncbi.nlm.nih.gov]

Myeloproliferative Disease

Extensive screening for thrombophilia was negative. [ncbi.nlm.nih.gov]

RESULTS: In this patient, several mechanisms may have played a role, including perioperative stress, thrombocytosis, thrombophilia, and associated chronic liver disease. [ncbi.nlm.nih.gov]

Treatment of adverse perinatal outcome in inherited thrombophilias: a clinical study A Kosar, B Kasapoglu, S Kalyoncu, H Turan, OS Balcik, EI Gümüs Blood coagulation & fibrinolysis [scholar.google.com]

Hemophilia B

Additional analyses of thrombophilic parameters did not reveal hints of systemic thrombophilia, suggesting that toxic and inflammatory effects of cytomegalovirus itself were [ncbi.nlm.nih.gov]

Simioni P, Tormene D, Tognin G, et al: X-linked thrombophilia with a mutant factor IX (factor IX Padua). [mayocliniclabs.com]

Hematology, Ogikubo Hospital, Tokyo, Japan; 6 Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Bonn, Germany; 7 Rush Hemophilia and Thrombophilia [ncbi.nlm.nih.gov]

Polycythemia Vera

Abstract Mechanical valve thrombosis is a rare condition in an adequately anticoagulated patient in the absence of underlying thrombophilia. [ncbi.nlm.nih.gov]

A work-up for JAK2 V617F mutation and thrombophilia was done. Medical charts and imaging tests were carefully reviewed. [ncbi.nlm.nih.gov]

[…] urgent liver transplantation (LT) in a patient with end-stage liver disease due to a Budd-Chiari syndrome, portal vein thrombosis and pulmonary embolism due to acquired thrombophilia [ncbi.nlm.nih.gov]

Acute Myocardial Infarction

Heritable thrombophilia and childhood thrombosis. Blood Rev. 2001 ; 15 : 181 – 189 de Veber G, Monagle P, Chang A, et al. [pediatrics.aappublications.org]

We speculate that the cause of MI in our case was paradoxical embolism via a PFO in a patient with inherited thrombophilia. [pediatrics.aappublications.org]

However, in adults, current clinical management of PFO in patients with demonstrated thrombophilia would include PFO closure. [pediatrics.aappublications.org]

Hemophilia

The Hemophilia and Thrombophilia Center at Rush is the largest program of its kind in Illinois. [rush.edu]

Program we provide a full range of consultative services for patients with deep vein thrombosis (DVT) and arterial thrombosis, including evaluation for hereditary and acquired thrombophilia [cancer.dartmouth.edu]

Interpatient phenotypic inconsistency in severe congenital hemophilia: a systematic review of the role of inherited thrombophilia. [nejm.org]

Heparin-Induced Thrombocytopenia

Hypercoagulability: Hereditary Thrombophilia and Lupus Anticoagulants Associated with Venous Thrombosis and Emboli. emedicine [On-line information]. [labtestsonline.org.tr]

[…] change 2019 (effective 10/1/2018) : No change Code annotations containing back-references to D75.82 : Type 1 Excludes: D68.6, D69.5 ICD-10-CM Diagnosis Code D68.6 Other thrombophilia [icd10data.com]

Guidance for the evaluation and treatment of hereditary and acquired thrombophilia // J. Thromb. [thrj.ru]

Inflammatory Bowel Disease Type 1

Review article: inherited thrombophilia in inflammatory bowel disease. [web.archive.org]

The role of the inherited thrombophilia has been recently reviewed[ 94 ]. [doi.org]

The role of the inherited thrombophilia has been recently reviewed [94]. [web.archive.org]

Oral Contraceptive

Our case suggests that a thrombophilia work-up may be warranted in BD patients, especially young women before they are prescribed oral contraceptives. [ncbi.nlm.nih.gov]

Furthermore, the exclusion of a hereditary thrombophilia and of alterations of coagulative parameters should precede any decision of combined oral contraceptive prescription [ncbi.nlm.nih.gov]

Psychogenic Hyperventilation

STUDY OBJECTIVE: Elevated arterial lactate levels are closely related to morbidity and mortality in various patient categories. In the present retrospective study, the relation between arterial lactate, partial pressure of carbon dioxide (Pco(2)) and pH was systematically investigated in patients who visited the[…] [ncbi.nlm.nih.gov]

Cerebral Thrombosis

[…] was noted in 34%, and an inherited thrombophilia was detected in 22%. 4 Inherited thrombophilias associated with cerebral venous thrombosis include deficiencies of antithrombin [circ.ahajournals.org]

Prevention of CVT is feasible through healthy lifestyle, genetic counseling, molecular genetic analysis for common thrombophilia-related mutations, and prophylactic anticoagulative [ncbi.nlm.nih.gov]

Thrombophilia Testing Because of the high frequency of thrombophilias among patients who develop cerebral venous thrombosis, screening for hypercoagulable conditions should [webmedcentral.com]

Thrombosis

This is called thrombophilia (thrahm-bo-FIL-ee-uh). [seattlechildrens.org]

Most patients with venous thromboembolism do not require thrombophilia testing, since the results will not affect management. [nejm.org]

Thrombosis is most often seen in individuals with a history of immobilization, obesity, malignancy, or hereditary thrombophilia. [amboss.com]

Deep Vein Thrombosis

Observational studies show that patients who have had VTE and have thrombophilia are at most at a slightly increased risk for recurrence. [doi.org]

This guideline covers the diagnosis and management of venous thromboembolic diseases in adults (aged 18 and over), and the role of thrombophilia testing. [nice.org.uk]

Management of inherited thrombophilia: guide for genetics professionals. [doi.org]

Lymphoma

Overview Lymphoma is a broad term for cancer that begins in cells of the lymph system. The two main types are Hodgkin lymphoma and non-Hodgkin lymphoma (NHL). Hodgkin lymphoma can often be cured. The prognosis of NHL depends on the specific type. Explore the links on this page to learn more about lymphoma[…] [cancer.gov]

Mesenteric Vein Thrombosis

Thrombophilia workup revealed double heterozygosity for factor V Leiden and prothrombin G20210A mutation. [ncbi.nlm.nih.gov]

Thromboembolic events may occur during an IVF cycle in the absence of overt ovarian hyperstimulation, an inherited thrombophilia, or pregnancy. [ncbi.nlm.nih.gov]

HCC) hypercoagulable state — thrombophilia, malignancy, pregnancy, trauma, inflammatory bowel disease (IBD), hypovolemia, oral contraceptive pill (OCP) endothelial activation [lifeinthefastlane.com]

Pancreatic Adenocarcinoma

BACKGROUND: Prognosis of patients with locally advanced or metastatic pancreatic adenocarcinoma is poor. In this study, we assessed the predictive value of easily available baseline factors for prolonged survival. PATIENTS AND METHODS: We conducted a retrospective study on patients who received gemcitabine between[…] [ncbi.nlm.nih.gov]

Thrombomodulin-Related Bleeding Disorder

An important gene associated with Thrombophilia Due to Thrombomodulin Defect is THBD (Thrombomodulin). [malacards.org]

Thrombophilia due to thrombomodulin defect (THPH12) [MIM:614486]: A hemostatic disorder characterized by a tendency to thrombosis. [genecards.org]

Thrombophilia and early pregnancy loss. Best Pract Res Clin Obstet Gynaecol. 2011 Nov 11. [Medline]. Aznar J, Villa P, España F, et al. [emedicine.medscape.com]

Coagulation Abnormalities

D68.51 Activated protein C resistance D68.52 Prothrombin gene mutation D68.59 Other primary thrombophilia D68.6 Other thrombophilia D68.61 Antiphospholipid syndrome D68.62 [icd10data.com]

We evaluated the etiologic role of thrombophilia in Legg-Calvé-Perthes disease in a pediatric population. [ncbi.nlm.nih.gov]

High Previous VTE + thrombophilia Previous VTE + family history of VTE Asymptomatic thrombophilia (antithrombin deficiency, combined defects, homozygous factor V Leiden or [frca.co.uk]

Superior Mesenteric Vein Thrombosis

A thrombophilia screen showed factor V 'Leiden' gene mutation (heterozygous) in both cases. [ncbi.nlm.nih.gov]

Thromboembolic events may occur during an IVF cycle in the absence of overt ovarian hyperstimulation, an inherited thrombophilia, or pregnancy. [ncbi.nlm.nih.gov]

MVT may be idiopathic or be caused by conditions responsible for thrombophilia and acquired risk factors. To date, there have been few reports of MVT after trauma. [ncbi.nlm.nih.gov]

Abruptio Placentae

Genes 2 genes associated with the disease abruptio placentae; fetal death; fetal growth retardation; intrauterine growth retardation; placenta abruptio; placenta diseases; thrombophilia [amp.pharm.mssm.edu]

BACKGROUND: It has been reported recently that obstetric complications are associated with thrombophilias. [ncbi.nlm.nih.gov]

[…] multiparity advanced maternal age polyhydramnios chorioamnionitis uterine malformations prior placental abruption multifetal gestations oligohydramnios uterine leiomyomas thrombophilias [bestpractice.bmj.com]