Presentation
Phylogenetic trees of the whole-genome, penton base, and fiber knob regions are presented in the top row with the hexon and its parts, “loop 1” and “conserved,” presented in the bottom row. All were generated after sequence alignments. [doi.org]
The presenting symptoms were varied in all of the groups studied and no particular presenting factor predicted the risk of associated haematuria. Haematuria is a frequent presentation requiring nephrological follow up. [adc.bmj.com]
The patients presented with sudden onset respiratory distress that progressed rapidly to respiratory failure and death. [ncbi.nlm.nih.gov]
Entire Body System
- Chronic Infection
They include: Chronic lung disease very rare may develop if a child develops pneumonia from adenovirus this strain of the virus has a 10 percent mortality rate >Severe infections Children with weakened immune systems are at risk Intussusception when one [childrenshospital.org]
In contrast, when adenoid tissue obtained during a symptom-free interval or from a chronically-infected carrier is analyzed, only a small number of cells seem to harbor the viral genome, which may not be intact. [web.archive.org]
Respiratoric
- Common Cold
Photo Credit: Pathology Laboratory Medicine 2016 Adenoviruses are one of the respiratory viruses that can cause the common cold. [health.hawaii.gov]
Adenoviruses are a group of viruses that cause respiratory (breathing) illnesses, such as a common cold, conjunctivitis (an infection in the eye), croup, bronchitis, bronchiolitis (inflammation of the lower airways), and pneumonia. [childrenshospital.org]
Adenoviruses can cause a wide range of illnesses such as Common cold Sore throat Bronchitis (a condition that occurs when the airways in the lungs become filled with mucus and may spasm, which causes a person to cough and have shortness of breath) Pneumonia [cdc.gov]
Symptoms of respiratory illness caused by Adenovirus infection range from the common cold syndrome to pneumonia, croup, and bronchitis. [certest.es]
Liver, Gall & Pancreas
- Jaundice
Most of the children affected are five years old or younger and have had symptoms of gastroenteritis illness - diarrhoea and nausea - followed by jaundice or yellowing of the skin and eyes (a sign that the liver is struggling). [bbc.com]
All patients presented with jaundice, or yellowing of the skin, and were tested and diagnosed with hepatitis. Two patients required liver transplants. [uab.edu]
Causes death with severe extensive hepatocyte damage on post mortem inspection Subacute- fever, conjunctivitis, nasal discharge, abdo pain, petichae of mucosa, leucoponeia, bleeding, DIC, vomiting, bloody di+, jaundice animal can recover- usually slow [quizlet.com]
“The symptoms of liver dysfunction to look out for in your child are diarrhea, vomiting, jaundice — yellow eyes and yellow skin, pain in the right side of their abdomen — particularly the upper area, fever, and other flu-like symptoms,” he says. [news.llu.edu]
Skin
- Blister
METHODS: The present study was mainly designed to compare the performance of two combined test strips for the detection of RV and AdV: a rotavirus-adenovirus strip with fluorescent microspheres for tracers (FMT); and the CerTest rotavirus-adenovirus blister [ncbi.nlm.nih.gov]
Neurologic
- Confusion
Symptoms include fever, headache, nausea and vomiting, stiff neck, and confusion. Is Adenovirus Contagious? Adenovirus is highly contagious. [kidshealth.org]
Adenoviridae Structure and Transmission In order to preemptively quench a potential source of confusion, I'm going to offer you a free sample of food for thought as you enter the store. [study.com]
[…] listed as recombinant vaccines and not confused with the limited production of Ad4 and Ad7 vaccines. [medicinenet.com]
- Burning Sensation
Acute adenoviral conjunctivitis is more common in individuals over 12 years old, while bacterial acute conjunctivitis is more common in children under 12.12 A burning sensation, an enlarged and painful preauricular lymph node, corneal involvement and [reviewofophthalmology.com]
The researcher's fever, cough, and pleuritic symptoms (“burning sensation in the lungs”) are consistent with the development of a prolonged viral respiratory illness. [doi.org]
Workup
A standard diagnostic workup for children with acute hepatitis should be done locally per treating clinicians. [dph.illinois.gov]
A routine microbiological workup for infectious causes of the outbreak, including bacterial, mycoplasma, and fungal cultures, was negative. [doi.org]
Biopsy
- Liver Biopsy
biopsy has already been performed as clinically indicated, or from native liver explant or autopsy: Formalin-fixed, paraffin embedded (FFPE) liver tissue Fresh liver tissue, frozen on dry ice or liquid nitrogen immediately or as soon as possible, and [dph.illinois.gov]
Liver biopsies showed mild-to-moderate active hepatitis in six patients, some with cholestasis (reduced or no bile flow), but immunohistochemical examination and electron microscopy revealed no sign of human adenovirus. [cidrap.umn.edu]
Liver biopsies indicated mild-to-moderate active hepatitis in 6 children, some with and some without cholestasis, but did not show evidence of human adenovirus on immunohistochemical examination or electron microscopy. [nejm.org]
WHO recommends that testing of blood (with initial anecdotal experience that whole blood is more sensitive than serum), serum, urine, stool, and respiratory samples, as well as liver biopsy samples (when available) should be undertaken, with further virus [who.int]
Treatment
This protocol facilitates rapid and cost-effective generation of virus-specific TCLs, which appear to provide an effective treatment option. [ncbi.nlm.nih.gov]
Other treatment, depending on the symptoms, may include intravenous fluids, oxygen, and breathing treatments. How Long Do Adenovirus Infections Last? Most adenovirus infections last from a few days to a week or two. [kidshealth.org]
Prognosis
Timely diagnosis and appropriate management are essential to improve the prognosis of adenovirus hepatitis in immunocompromised patients. [ncbi.nlm.nih.gov]
The prognosis declines as the severity of disease increases. [medicinenet.com]
Etiology
LESSON: Although the most common cause that leads to HUS remains STEC, other etiologies like viral ones that may be responsible for severe enteric infection with progression into HUS should not be neglected. [ncbi.nlm.nih.gov]
The difference in testing methods should be considered when designing surveillance studies “to estimate the burden of viral etiologies of respiratory diseases,” the researchers said. [healio.com]
We analyzed 59 norovirus-positive cases with known etiology and 66 norovirus-negative cases with unknown etiology from eight different norovirus outbreaks for the presence of HAdV-52 via PCR. [doi.org]
Epidemiology
Child Child, Preschool China/epidemiology Conjunctivitis/epidemiology Conjunctivitis/etiology* Conjunctivitis/virology DNA, Viral/isolation & purification DNA, Viral/metabolism Female Genotype Humans Infant Infant, Newborn Logistic Models Male Middle [ncbi.nlm.nih.gov]
Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 53 (11), 79. https://apps.who.int/iris/handle/10665/221792 Revue Weekly Epidemiological Record = Relevé épidémiologique hebdomadaire, 53 (11): 79 [apps.who.int]
Epidemiologic features: Although epidemiologic characteristics of the adenoviruses vary by type, all are transmitted by direct contact, fecal-oral transmission, and occasionally waterborne transmission. [web.archive.org]
Other epidemiological feature was as follows: EAd were detected throughout the year. The predominant serotype was Ad40 during 1980-1985, while Ad41 were observed after 1986. EAd were detected most frequently from the children aged 0-3 years. [doi.org]
Pathophysiology
We discuss the differential diagnosis and pathophysiology of allograft viral infections and concomitant rejection. [ncbi.nlm.nih.gov]
Many adenovirus infections are subclinical or asymptomatic. 15–70% of conjunctivitis worldwide Etiology and Pathophysiology DNA virus 60 to 90 nm in size, 6 species (A through F) with >50 known serotypes Adenovirus can remain dormant in lymphoreticular [unboundmedicine.com]
Pathophysiology Adenovirus is a double-stranded DNA virus that measures 70-90 nm and that has an icosahedral capsid. [emedicine.medscape.com]
There is little information about the epidemiology, pathophysiology and the usual route of infection of Ad-36. Human adenoviruses are associated with infection of the respiratory tract, gastrointestinal tract, and conjunctiva. [doi.org]
Prevention
Author information 1 Beijing Center for Disease Prevention and Control, No.16, Hepingli Middle Road, Beijing, 100013, People's Republic of China. 2 Research Centre for Preventive Medicine of Beijing, No.16, Hepingli Middle Road, Beijing, 100013, People's [ncbi.nlm.nih.gov]
For guidance to prevent adenovirus infections in healthcare settings, see Prevention & Treatment for Health Care Professionals. Treatment There is no specific treatment for people with adenovirus infection. [cdc.gov]
Additional resources The CDC—Adenoviruses Children’s Hospital of Philadelphia—Adenovirus infections APIC Infection Prevention and You—Infection Prevention Basics [apic.org]