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Cyclothymic Disorder
Affective Personality

Cyclothymic disorder (CD), also termed cyclothymia, is a mental disorder with mild but long-lasting and severely impairing mood swings. Characteristic mood changes include periods of euphoria which are abruptly followed by depressive episodes.

CD is part of the spectrum of bipolar disorders and can progress to bipolar disorder type 1 or 2. Onset usually occurs in adolescence and affects both genders equally. Prevalence is estimated to be up to 1/100. Progression to bipolar disorder occurs in up to 50% of cases.

CD may only be diagnosed if the specific mood swings persist for two years in adults or one year in adolescents.

Images

WIKIDATA, CC BY-SA 4.0

Presentation

Expert consensus defines cyclothymic disorder (CD) as a subclinical variant of bipolar disorder, which is characterized by chronic mood swings alternating between hypomanic and depressive periods. Due to the subclinical nature of CD, it has also been incorrectly assessed as a character trait in the past [1] [2] [3].

A cardinal feature of all types of bipolar disorders is perturbed sleeping, which also applies to CD [4] [5]. Long-term studies have shown that CD is as debilitating as other disorders of the bipolar spectrum [6] [7].

Hypomanic episodes may manifest with general euphoria, exaggerated self-esteem, logorrhea, impaired risk assessment, distractability, lack of concentration, racing thoughts, no need for sleep and marked irritability [1] [3].

CD patients have described their depressive periods with a feeling of fatigue, demoralization, persistent irritability, restlessness, guilt, low self-esteem and sleep disturbances together with weight changes and even suicidal thoughts [1] [8].

CD shows significant clinical overlap with major depressive episodes and bipolar disorders type 1 and 2 and can progress to the latter [9]. The exact etiology of CD remains unknown.

Workup

Diagnosing cyclothymic disorder requires a physical examination to check for potential causes of mood swings, a psychological evaluation to analyze the patient's mood swings with questionnaires and professional interviews. The patient's family and close friends may be included in this psychological analysis to obtain a complete picture of the mood swings and their frequency. Moreover, cases should keep track of their mood swings with a mood chart and record their sleeping hours.

Clinical criteria for CD are persistent episodes of hypomania and depression for at least one year in adolescents and two years in adults with intermittently stable mood periods shorter than two months. Characteristic findings cannot be traced back to other causes like substance abuse, and significantly affect the patient's social interactions [1].

Hypomanic CD symptoms in children are hard to distinguish from characteristic attention deficit hyperactivity disorder (ADHD) signs making CD a non-trivial diagnosis. Manic episodes never occur in CD [3] [10].

Progression of CD to bipolar disorder type 1 and 2 can be prevented with professional treatment. A late onset of CD hints towards substance abuse.

Treatment

Treatment for Cyclothymic Disorder typically involves a combination of psychotherapy and medication. Cognitive-behavioral therapy (CBT) is often used to help individuals manage symptoms and develop coping strategies. Medications such as mood stabilizers or atypical antipsychotics may be prescribed to help regulate mood swings. Regular follow-up with a mental health professional is essential to monitor progress and adjust treatment as needed.

Prognosis

The prognosis for Cyclothymic Disorder varies. With appropriate treatment, many individuals can achieve significant symptom relief and lead fulfilling lives. However, without treatment, the disorder can persist and potentially progress to a more severe mood disorder, such as Bipolar I or II Disorder. Early intervention and ongoing management are key to improving outcomes.

Etiology

The exact cause of Cyclothymic Disorder is not fully understood, but it is believed to result from a combination of genetic, biological, and environmental factors. A family history of mood disorders may increase the risk of developing Cyclothymic Disorder. Neurotransmitter imbalances in the brain and stressful life events may also play a role in its development.

Epidemiology

Cyclothymic Disorder is relatively rare, with an estimated lifetime prevalence of 0.4% to 1% in the general population. It affects both men and women, although some studies suggest it may be slightly more common in women. The disorder often begins in adolescence or early adulthood, but it can occur at any age.

Pathophysiology

The pathophysiology of Cyclothymic Disorder is not well-defined, but it is thought to involve dysregulation of mood-related neurotransmitters, such as serotonin, norepinephrine, and dopamine. These chemical imbalances may affect the brain's ability to regulate mood and emotional responses, leading to the characteristic mood swings of the disorder.

Prevention

There is no known way to prevent Cyclothymic Disorder, but early recognition and treatment of symptoms can help manage the condition and prevent progression to more severe mood disorders. Maintaining a healthy lifestyle, managing stress, and seeking support from mental health professionals can also contribute to better outcomes.

Summary

Cyclothymic Disorder is a chronic mood disorder characterized by fluctuating periods of hypomanic and depressive symptoms. While less severe than Bipolar Disorder, it can still significantly impact an individual's life. Diagnosis involves a thorough clinical evaluation, and treatment typically includes psychotherapy and medication. Understanding the disorder's etiology, epidemiology, and pathophysiology can aid in managing symptoms and improving prognosis.

Patient Information

If you or someone you know is experiencing mood swings that affect daily life, it may be helpful to learn more about Cyclothymic Disorder. This condition involves periods of elevated mood and energy, as well as periods of low mood and fatigue. Treatment options are available and can help manage symptoms effectively. It's important to seek guidance from a healthcare professional to explore the best approach for managing this condition.

References

  1. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th edition. Washington DC: American Psychiatric Association; 2001.
  2. Akiskal H, Khani M, Scott-Strauss A. Cyclothymic temperamental disorders. Psychiatr Clin North Am. 1979;2:527–554.
  3. Van Meter AR, Youngstrom EA. Cyclothymic disorder in youth: why is it overlooked, what do we know and where is the field headed?. Neuropsychiatry (London). 2012; 2(6): 509–519.
  4. Geller B, Zimmerman B, Williams M, DelBello M, Frazier J, Beringer L. Phenomenology of prepubertal and early adolescent bipolar disorder: examples of elated mood, grandiose behaviors, decreased need for sleep, racing thoughts and hypersexuality. J Child Adolesc Psychopharmacol. 2002;12(1):3–9.
  5. Harvey A, Mullin B, Hinshaw S. Sleep and circadian rhythms in children and adolescents with bipolar disorder. Dev Psychopathol. 2006;18(4):1147–1168.
  6. Birmaher B, Axelson D, Goldstein B, et al. Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the course and outcome of bipolar youth (COBY) study. Am J Psychiatry. 2009;166(7):795–804.
  7. Kessler R, Avenevoli S, Merikangas K. Mood disorders in children and adolescents: an epidemiologic perspective. Biol Psychiatry. 2001;49(12):1002–1014.
  8. Tomba E, Rafanelli C, Grandi S, Guidi J, Fava GA. Clinical configuration of cyclothymic disturbances. J Affect Dis. 2012; 139(3):244-249.
  9. Vieta E, Reinares M, Rosa AR. Staging bipolar disorder. Neurotox Res. 2011;19(2):279–285.
  10. Van Meter AR, Youngstrom EA, Findling RL. Cyclothymic disorder: A critical review. Clin Psych Rev. 2012; 32(4):229-243.
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