Presentation
The neutrophils in the bronchoalveolar space present as a heterogeneous population with very few pre-/pro-Neu and three mature subsets. [frontiersin.org]
Treatment
Further, the aforementioned Navarixin, together with other CXCR2 inhibitors, has been proposed as treatment for COVID-19 (95). [frontiersin.org]
Etiology
Clearly, much more work is necessary to comprehensively connect the transcriptionally described subpopulations to cellular functions as well as their role in etiologies and disease outcomes. [frontiersin.org]
Pathophysiology
Neutrophils in COVID-19 Pathophysiology of severe COVID-19 is marked by altered neutrophil abundance, phenotype and functionality. [frontiersin.org]
Prevention
Here, the HIF-NFκB axis represents an additional checkpoint to prevent unwanted effector functions. HIF-1α is expressed at low levels in circulating neutrophils, but upregulated in hypoxic conditions of inflamed tissue (34). [frontiersin.org]