Presentation
Abstract Hypertrichosis lanuginosa congenita is a rare, autosomal dominant cutaneous disorder with sporadic presentations reported. [ncbi.nlm.nih.gov]
Abstract Abstract: Hypertrichosis lanuginosa congenita is a rare, autosomal dominant cutaneous disorder with sporadic presentations reported. [doi.org]
Entire Body System
- Malnutrition
Generalised acquired hypertrichosis may be associated with: Porphyria cutanea tarda Malnutrition, eg anorexia nervosa Malignancy Drug, eg ciclosporin, phenytoin, androgenic steroids, minoxidil. [dermnetnz.org]
Hypertrichosis is much less common and can be seen with certain genetic conditions, drugs, malnutrition, hypothyroidism, and other diseases, such as porphyria. Polycystic ovarian syndrome accounts for 3/4 of Hirsutism cases. [youtube.com]
Hypertrichosis is a genetic disorder that triggers uncontrolled hair growth due to physical defects like non-functioning of endocrine gland, infections, mutation, malnutrition, drugs or hereditary factors. [werewolves.com]
- Dysostosis
Various genodermatosis associated with hypertrichosis as the main or secondary diagnostic symptom are: Lipoatrophy (Lawrernce Seip syndrome) Cornelia de Lange syndrome Craniofacial dysostosis Winchester syndrome Rubinstein–Taybi syndrome Mucopolysaccharidoses [ncbi.nlm.nih.gov]
Craniofacial dysostosis, hypertrichosis, genital hypoplasia, ocular, dental, and digital defects: confirmation of the Gorlin-Chaudhry-Moss syndrome. Am J Med Genet. 1992 Nov 1;44(4):518-22. [disorders.eyes.arizona.edu]
Craniofacial dysostosis Is often associated with cardiac anomalies, hypoplasia of the labia majora, together with abnormalities of the teeth and eyes [7]. [ijponline.biomedcentral.com]
- Underweight
For example, if a person with anorexia nervosa becomes severely underweight, the body often responds to the loss of insulating body fat by growing a fine layer of lanugo to keep warm. [verywellhealth.com]
Jaw & Teeth
- Macrostomia
Macrostomia and thin lips with redundant facial skin are often evident. The nose appears bulbous. The thoracic skin can be atrophic and the nipples may be hypoplastic. Hypospadias has been reported. [disorders.eyes.arizona.edu]
Clinical description BBS presents with congenital generalized hypertrichosis, facial dysmorphism (typically with bilateral ectropion, absent or sparse eyebrows and lashes, hypertelorism/telecanthus, broad nasal bridge, bulbous nose, anteverted nostrils, macrostomia [orpha.net]
Macrostomia, ectropion, atrophic skin, hypertrichosis and growth retardation. Syndr Indent 1982;8:6-9. 23. David A, Gordeeff A, Badoual J, Delaire J. Macrostomia, ectropion, atrophic skin, hypertrichosis: Another observation. [ijtrichology.com]
230818 •Concept ID: C1319466 • Disease or Syndrome Barber-Say syndrome is a rare congenital condition characterized by severe hypertrichosis, especially of the back, skin abnormalities such as hyperlaxity and redundancy, and facial dysmorphism, including macrostomia [ncbi.nlm.nih.gov]
Barber-Say syndrome Aside hypertrichosis, patient with Barber-Say syndrome present atrophic lax skin, macrostomia, broad and coarse eyebrows, an hairy bulbous nasal tip with hypoplastic flaring nostrils, telecanthus and hypoplastic nipples. [ijponline.biomedcentral.com]
- Microdontia
Hypo- and microdontia with irregularly spaced teeth and a high arched palate are common features. Clefts of the soft palate has been observed. The ears can be small and rotated posteriorly. [disorders.eyes.arizona.edu]
Common features include cryptorchidism, speech impairment, and clinodactyly of the fifth finger, Some patients exhibit visual disturbances, polydactyly, seizures, and/or ectodermal abnormalities, such as nail hypoplasia, long eyelashes, hirsutism, and microdontia [ncbi.nlm.nih.gov]
- Small Teeth
You also have very small teeth. How do you defend yourself? I use The Force. Facebook + Atchoum's Fan Does your condition make it difficult for you to groom yourself? Is that ever frustrating? I have a human slave that grooms me. [cosmopolitan.com]
Skin
- Hypertrichosis
From Wikimedia Commons, the free media repository Jump to navigation Jump to search hypertrichosis hair disease characterized by hair growth that is abnormal in quantity or location Upload media Wikipedia Instance of class of disease Subclass of hair [commons.wikimedia.org]
Hypertrichosis can develop all over the body or can be isolated to small patches. Hypertrichosis may be congenital (present at birth) or acquired (arises later in life). What causes hypertrichosis? The cause of hypertrichosis is unknown. [dermnetnz.org]
Hypertrichosis website. http://www.hypertrichosis.com/. Hypertrichosis lanuginosa congenital. Genetic and Rare Diseases Information Center (GARD). National Institutes of Health website. [medicalbag.com]
For example, terminology has included hypertrichosis universalis, hypertrichosis lanuginosa, congenital hypertrhicosis lanuginosa, and hypertrichosis universalis lanuginosa. [dermatology.cdlib.org]
- Hirsutism
hypertrichosis excessive hairiness; hirsutism. [medical-dictionary.thefreedictionary.com]
Synonyms Acquired hypertrichosis lanuginosa Androgen dependent hirsutism Androgen-dependent hirsutism Familial hirsutism Hirsutism (excess body hair) Hirsutism in female, androgen dependent Hirsutism, familial Hirsutism, idiopathic Hypertrichosis Hypertrichosis [icd9data.com]
Androgens and hirsutism Hirsutism may be a sign of a significant medical disorder. Hirsutism is caused by increased androgen action on hair follicles. [web.archive.org]
Hypertrichosis is excessive hair growth over and above the normal for the age, sex and race of an individual, in contrast to hirsutism, which is excess hair growth in women following a male distribution pattern. [dermnetnz.org]
Treatment for hirsutism itself is necessary only if the patient finds the excess hair cosmetically objectionable. Patients with androgen-dependent hirsutism require a combination of hair removal and antiandrogen therapy. [msdmanuals.com]
- Hyperhidrosis
This is the first case of FHI presenting with hyperhidrosis and hypertrichosis reported in Korea. © 2018 The Korean Academy of Medical Sciences. KEYWORDS: Fibrous Hamartoma of Infancy; Hyperhidrosis; Hypertrichosis; Korean [ncbi.nlm.nih.gov]
[…] free encyclopedia Jump to navigation Jump to search X-linked hypertrichosis Specialty Dermatology X-linked hypertrichosis is a hereditary disorders characterized by generalized congenital hypertrichosis and thick eyebrows.[1] See also[edit] Generalized hyperhidrosis [en.wikipedia.org]
[…] sindrom dlani in podplatov), prekomerno znojenje (hiperhidroza), kožna reakcija (dermatitis), English kin ulcer; scab; excess hair growth (hypertrichosis); redness and swelling of palms of hands or soles of feet (hand-foot syndrome); excess sweating (hyperhidrosis [mymemory.translated.net]
Pheochromocytomas (see Neuroendocrine Tumors ) may cause hyperhidrosis, hyperglycemia, and tachypnea, although they usually are nonfunctional and found only incidentally at necropsy. [msdvetmanual.com]
- Sweating
obarvanje kože, hipertrihoza, English Exfoliative rash, skin exfoliation, necrolytic migratory erythema, blood blister, dermatitis allergic, skin reaction, dermatitis acneiform, erythema, increased tendency to bruise, purpura, hyperhidrosis, night sweats [mymemory.translated.net]
[…] the woman may also present with male physical characteristics, such as deepening of voice, loss of normal female contour, breast atrophy, male pattern obesity, clitoromegaly increased muscle mass, androgenic alopecia, increased libido and malodorous sweating [lecturio.com]
Face, Head & Neck
- Thick Lips
(D) A 13-year-old bearded girl (II-2 of family BJ) showing a coarse face with bushy and dark eyebrows, long eyelashes, a bulbous soft nose, large ears with thick and hairy lobes, and thickened lips. [ncbi.nlm.nih.gov]
It is characterized by dwarfism with a peculiar elfin-like face, large eyes, thick lips and low set ears. [ijponline.biomedcentral.com]
Workup
Workup of Hirsutism History Age of onset : Hirsutism, which is noticed from puberty, is indicative of idiopathic hirsutism. Hirsutism starting at middle/older age is indicative of adrenal or ovarian tumors. [lecturio.com]
Therefore, a clinical diagnostic workup to rule out these pathologies is necessary. [dovepress.com]
Treatment
Drug-induced hypertrichosis What is the treatment for hypertrichosis? Treatment of hypertrichosis is basically hair removal. Several methods are available but need to be repeated regularly as hair continues to grow back. [dermnetnz.org]
After 10 years, the areas of paradoxical hair growth were sparser compared to immediate post-treatment but remained denser compared to pre-treatment. This case illustrates improvement in the condition over time without intervention. [ncbi.nlm.nih.gov]
Summary Generalized hypertrichosis is a common side‐effect of oral minoxidil treatment for hypertension. [doi.org]
Prognosis
[…] lichen planus lotion lupus lymph-nodes majority of instances malady mercury nails nodules occasionally occur ointment oval papilla papillary papular papules particularly patches patient pediculosis pemphigus percent Phila pigmentation present probably Prognosis [books.google.com]
Because acquired hypertrichosis lanuginosa typically occurs late in the course of the malignancy, the overall prognosis is poor. However, regression of hair growth is known to occur if the tumour is treated or removed. [dermnetnz.org]
Management and prognosis The current literature focuses predominantly on diagnosis of AS cases rather than management. The first described patient, Petrus Gonzales, lived a long life and was able to procreate [ 1 ]. [dermatology.cdlib.org]
Management and prognosis The current literature focuses predominantly on diagnosis of AS cases rather than management. The first described patient, Petrus Gonzales, lived a long life and was able to procreate [1]. [escholarship.org]
Suitable technologies include 755nm Alexandrite laser, 1064nm Nd:Yag laser, diode laser, intense pulsed light (IPL) and electrolysis. [49] Prognosis The prognosis of hypertrichosis varies, depending on the type of hypertrichosis. [ncbi.nlm.nih.gov]
Etiology
—The dilated disease disorder eczema employed epidermis eruption erythema Etiology Etiology and Pathology. [books.google.com]
Despite an attempt to find etiologic factors in our patients and in the literature, none could be elicited. [ncbi.nlm.nih.gov]
Certain conditions have both an underlying etiology and multiple body system manifestations due to the underlying etiology. [icd10coded.com]
Epidemiology
Summary Epidemiology BBS is a rare entity described in eleven patients to date. [orpha.net]
The longer wavelength Nd: YAG laser is considered safest in treating darker skin phototypes. [6] Reporting such rare syndromes not only adds to the database, but pooled data analysis may give us a better insight into patterns of inheritance, epidemiology [ijdvl.com]
Descriptive epidemiology of Cornelia de Lange syndrome in Europe. Am J Med Genet A. 2008;146A:51-59. 5. Schaffer JV, Chang MW, Kovich OI, et al. Pigmented plexiform neurofibroma: distinction from a large congenital melanocytic nevus. [consultant360.com]
Epidemiology of Hirsutism Hirsutism affects around 10 % of women in the US. Hirsutism is one of the most common health problems of women in reproductive age. The prevalence ranges from 4.3 to 10.8 % in blacks and whites respectively. [lecturio.com]
[…] localized hypertrichosis can also be iatrogenic; it has been described following PUVA therapy, topical corticosteroids, tacrolimus, creams containing mercury or iodine, anthralin, and prostaglandin F-2 alpha analogues (latanoprost, bimatoprost).[31] Epidemiology [ncbi.nlm.nih.gov]
Pathophysiology
Stimulation of the growth of hair via adrenal androgens by thyroid stimulating hormone may be the pathophysiological mechanism in our patient. [nature.com]
Aetiology and pathophysiology of hair loss. Dermatologica. 1987;175 Suppl 2:23-8. PubMed 11. Macias-Flores MA, Garcia-Cruz D, Rivera H, Escobar-Lujan M, Melendrez-Vega A, Rivas-Campos D, Rodriguez-Collazo F, Moreno-Arellano I, Cantu JM. [dermatology.cdlib.org]
Hypertrichosis of the auricle and hypertrichosis of the nasal tip, types of hereditary hypertrichosis, primarily affect males.[32][33] Pathophysiology The pathophysiology of hypertrichosis varies depending on the etiology. [ncbi.nlm.nih.gov]
Prevention
Hormonal therapy and antiandrogen therapy can help to reestablish the balance of estrogen to androgen, this reduces current hair and preventing further growth. [youtube.com]
However, this often results in hypertrichosis that can be severe enough to prevent its use. Diazoxide blocks insulin release from the pancreas by opening the SUR1/Kir6.2 channels in ß-cells. [ncbi.nlm.nih.gov]
Women should be warned not to expect improvement or at least 3–6 months after therapy is begun and lifelong therapy may be needed to prevent recurrence. [doi.org]