A lumbar compression fracture involves the lumbar vertebrae and occurs typically secondary to bone demineralization. It is seen in postmenopausal women and in the elderly due to osteoporosis but may also be associated with malignancies. Therefore a thorough workup is essential to detect the fracture and its cause.
Presentation
Although compression fractures can occur anywhere along the vertebral column, they are most common at the thoracolumbar junction involving the T8-T12, L1, and L4 vertebrae [1]. The incidence of this condition increases steadily with advancing age [2]. Lumbar compression fractures can be asymptomatic and may be detected incidentally in the elderly on lumbar X-rays or may present insidiously with a backache. The pain is typically in the midline, aching or stabbing in quality, non-radiating and severe enough to cause disability and interfere with activities of daily living. The pain is usually relieved by lying supine and is aggravated by standing or walking. The pain often persists even after the fracture has healed [3]. However young adults with lumbar compression fractures may be diagnosed with a severe back pain of sudden onset and neurologic deficits in the lower limbs following a vehicular accident. The incidence of associated radiculopathy increases with descending spinal levels [4]. In the elderly, multiple fractures over a period of time lead to decrease in height and stature with subsequent paraspinal muscle shortening, lumbar lordosis, and thoracic kyphosis. As a result, the individual has to actively contract the paraspinal muscles to maintain posture leading to fatigue and in severe cases, it can lead to impaired lung function, abdominal protuberance, compression of abdominal organs with early satiety and loss of weight [5].
Individuals with lumbar compression fractures secondary to malignancies like multiple myeloma or metastasis may present with fever of unknown origin, night sweats, anorexia, weight loss or a history of a previous breast or prostate malignancy.
Workup
Lumbar compression fracture should be suspected in postmenopausal women and the elderly who present with sudden onset severe lumbar pain. Many patients may remember a specific injury [6] although the condition may present without any prior history of trauma. Tenderness is typically elicited on palpating directly over the fracture site and there may also be kyphosis [7]. A thorough neurological examination is necessary but may not reveal any deficits in uncomplicated fractures.
Plain X-rays of the spine will confirm the diagnosis and reveal the classic wedge deformity corresponding to the site of maximum tenderness. A reduction in vertebral height by 20% or a decrease of at least 4 mm compared to the baseline height is an indication of a compression fracture [6]. Ideally, the entire spine should be imaged to exclude multiple fractures and occasionally serial imaging may be required to detect the fracture.
Techniques like computed tomography (CT), magnetic resonance imaging (MRI) help in diagnosis by excluding the other etiologies of back pain. They also confirm the integrity of the posterior vertebral wall [8]. In addition, a CT can detect a compression fracture (not visualized on plain radiographs), spinal canal narrowing and differentiate between a compression fracture and a burst fracture. An MRI is indicated in patients with neurologic deficits, or if a malignancy is suspected as the underlying cause of the lumbar compression fracture. Positron emission tomography (PET) can also be ordered to differentiate between compression fractures of benign versus malignant etiology.
Laboratory tests like erythrocyte sedimentation rate, complete blood count (CBC), prostate-specific antigen testing, serum protein electrophoresis to exclude multiple myeloma and urinalysis for Bence-Jones proteins should be routinely performed. Bone density scanning is recommended to measure the severity of osteoporosis and for further patient management [9].
Treatment
Treatment for lumbar compression fractures depends on the severity of the fracture and the underlying cause. Conservative management includes pain relief with medications, rest, and physical therapy to strengthen the back muscles and improve mobility. In cases where the fracture is severe or does not respond to conservative treatment, surgical options such as vertebroplasty or kyphoplasty may be considered. These procedures involve the injection of bone cement into the fractured vertebra to stabilize it and relieve pain.
Prognosis
The prognosis for lumbar compression fractures varies depending on the cause and severity of the fracture. Many patients experience significant pain relief and improved function with appropriate treatment. However, if the fracture is due to osteoporosis, there is a risk of future fractures unless the underlying bone health is addressed. Early diagnosis and treatment are crucial for preventing complications and improving outcomes.
Etiology
Lumbar compression fractures are most commonly caused by osteoporosis, a condition characterized by decreased bone density and increased fragility. Other causes include trauma, such as falls or accidents, and pathological conditions like cancer that weaken the bones. In rare cases, certain medical treatments or conditions that affect bone health can also lead to compression fractures.
Epidemiology
Lumbar compression fractures are more prevalent in older adults, particularly postmenopausal women, due to the higher incidence of osteoporosis in this population. The risk increases with age, and individuals with a history of fractures or conditions affecting bone health are at greater risk. Men can also be affected, especially if they have risk factors for osteoporosis.
Pathophysiology
The pathophysiology of lumbar compression fractures involves the collapse of the vertebral body, which can occur when the bone is weakened by conditions like osteoporosis. The loss of bone mass reduces the structural integrity of the vertebrae, making them more susceptible to fractures under normal stress or minor trauma. This collapse can lead to changes in spinal alignment and potential compression of the spinal cord or nerves.
Prevention
Preventing lumbar compression fractures primarily involves addressing the underlying risk factors, particularly osteoporosis. This can include lifestyle modifications such as a diet rich in calcium and vitamin D, regular weight-bearing exercise, and avoiding smoking and excessive alcohol consumption. Medications to strengthen bones may be prescribed for individuals at high risk of fractures. Regular bone density screenings can help identify those at risk and guide preventive measures.
Summary
Lumbar compression fractures are a common condition, especially among older adults with osteoporosis. They can cause significant pain and disability but are often manageable with appropriate treatment. Early diagnosis and intervention are key to preventing complications and improving quality of life. Understanding the risk factors and implementing preventive strategies can help reduce the incidence of these fractures.
Patient Information
If you suspect a lumbar compression fracture, it is important to seek medical evaluation. Symptoms include sudden back pain, reduced height, and difficulty moving. Diagnosis typically involves imaging studies like X-rays. Treatment may include pain management, physical therapy, and possibly surgery. Preventive measures focus on maintaining bone health through diet, exercise, and lifestyle changes. Regular check-ups and bone density tests can help manage risk factors effectively.
References
- Patel U, Skingle S, Campbell GA, Crisp AJ, Boyle IT. Clinical profile of acute vertebral compression fractures in osteoporosis. Br J Rheumatol. 1991;30:418–21.
- Melton LJ 3d, Kan SH, Frye MA, Wahner HW, O'Fallon WM, Riggs BL. Epidemiology of vertebral fractures in women. Am J Epidemiol. 1989;129:1000–11.
- American Geriatrics Society. The management of chronic pain in older persons: AGS panel on chronic pain in older persons. J Am Geriatr Soc. 1998;46: 635–51.
- Kim DE, Kim HS, Kim SW, Kim HS. Clinical analysis of acute radiculopathy after osteoporotic lumbar compression fracture. J Korean Neurosurg Soc. 2015 Jan; 57 (1):32-5.
- Silverman SL. The clinical consequences of vertebral compression fracture. Bone. 1992;13Suppl 2: S27–31.
- Nevitt MC, Ettinger B, Black DM, et al. The association of radiographically detected vertebral fractures with back pain and function: a prospective study. Ann Intern Med. 1998;128:793–800.
- Bratton RL. Assessment and management of acute low back pain. Am Fam Physician. 1999;60:2299–308.
- Predey TA, Sewall LE, Smith SJ. Percutaneous vertebroplasty: a new treatment for vertebral compression fractures. Am Fam Physician. 2002;66:611–5.
- Ullom-Minnich P. Prevention of osteoporosis and fractures. Am Fam Physician. 1999;60:194–202.