In the United States, 36% of the population are clinically obese as of 2010. Obesity remains to be a looming major health crisis internationally where its prevalence rate is increasing rapidly especially in the first world countries worldwide [1].
Presentation
Obesity is technically defined as having a BMI of more than 30. BMI is an index that reflects the body weight in kilograms divided by the height of the individual in meters squared. Obese patients usually present with higher anthropometric measurements which include waist circumference, hip circumference, and thigh circumference. The neck circumference is also an effective parameter in determining the risk for sleep apnea in most obese patients [9]. Joint deformities may frequently be observed for it bears the weight of the unusually large body mass.
Workup
Patients that are seen to be obese with BMI of more than 30 are subjected to a more detailed clinical interview with emphasis on metabolic habits and genetic predispositions, and a meticulous physical examination inclusive of the standard anthropometric measurements for comparison. The following ancillary tests are done on an obese patient:
- BMI measurement: The body mass index is an accurate measure of the relative risk of one on cardiovascular diseases. This can also be used as a monitoring index in weight reduction regimens.
- Vital signs: The blood pressure readings, pulse rate and respiratory rate may be adversely affected by the obese conditions.
- Blood tests: Obese patients may be at risk with other concomitant medical illnesses. Blood cholesterol, blood sugar levels, thyroid function tests, and liver function test may be imperatively monitored for any abnormalities.
- Electrocardiograph: This tool will involve electrodes placed on the chest to determine the condition of the heart impulses because cardiovascular risk is always higher in obesity.
Treatment
The general goal in the treatment of obesity is to achieve the healthy weight level. Weight reduction regimens are dependent on the level of obesity [10]. The following treatment tools are usually implored on obese patients:
- Dietary modification
- Regular exercise
- Behavioral and attitude change
- Weight loss medications
- Weight reduction surgery (Bariatric surgery)
Prognosis
Recent researches in endocrinology and metabolic sciences have implicated obesity to increase the mortality and morbidity of patients with comorbid cardiovascular diseases [8]. Obesity is also associated with a significant increase of all-cause mortality and morbidity rating. Furthermore, obese patients with body mass index (BMI) of more than 28 are associated with an almost two fold risk of cardiac diseases and cerebral stroke.
Etiology
Obesity occurs as a combination of several contributing factors. The following factors are established to be contributory to the development of obesity among susceptible patients:
- Genetics: Patients born from an obese family iare likely to be obese.
- Hormonal influence: This includes intrinsic and exogenous hormones.
- Inactivity: Prolonged inactivity or sedentary lifestyle burns lesser dietary calories than what is actually taken in leading to obesity.
- Unhealthy eating habits: An exclusively carnivorous diet and by eating excessive portions in a meal may predispose one to weight development problems in the future.
- Lack of sleep: The perennial habit of shortened sleeping time may alter one’s hormones that advertently increases appetite and cravings for high caloric meals and beverages.
- Pregnancy: Hormonal induction during pregnancy leads to weight gain among expectant mothers.
- Medications: Some medications intrinsically increase the weight and boost the appetite. An example of these includes corticosteroids, anti-diabetics, anti-depressants, and beta blockers.
- Medical issues: Some medical conditions predisposes one to be obese. These medical conditions includes Cushing syndrome, Prader-Willi syndrome, and hypothyroidism.
Epidemiology
In the United States, more than 90 million of the population including men, women, and children are noted to be obese. Prevalence rate of obesity are even more pronounced in some minority groups like the Prima Indians, Afro-Americans, and the Latin Americans [3]. Obese and overweight individuals account for 1 out of 5 deaths in the United States today [4].
The worldwide prevalence of obesity has been steadily increasing especially in the northern hemisphere and Europe. Today, approximately 22% of the female and 15% of the male are obese in Europe [5]. Because women physiologically have a higher fat content than male, obesity has a greater predilection to women than in men. Conservatively, the currently global estimates suggests that 7% of the world population are obese. Obese children are most likely to obese when the reach adulthood.
Pathophysiology
There are practically two types of obesity in relation to adipocyte (fat cells) development, the hypercellular obesity, and the hypertrophic obesity. Hypertorphic obesity is associated with the increasing size of adipocytes found in majority of cases like the android abdominal obesity. This is the type of obesity found in adulthood that is easily responsive to weight reduction treatments.
The hypercellular obesity type usually occurs among obese individual that starts out as an obese adolescent and may also occur among the severely obese adult patients. Recent researches are unearthing the possibilities that certain adipocytes in the body may functionally serve as an endocrine gland that regulates weight gain [6]. The involvement of insulin in the control the olfactory senses during the actual act of eating has been intensively investigated in the pathogenesis of obesity [7].
Prevention
The main goal in the prevention of obesity is practically very similar to the approach in weight reduction programs for the obese patient. One is regularly encourage to do exercises and monitor one’s weight and BMI. Dietary restriction of unhealthy foods should be practiced and an avid monitoring of the calories ingested daily should be in place.
Summary
Obesity is revered to be a complex medical condition involving excessive amounts of body and visceral fats. Obesity does not only distort the overall physique of the person, but it also increases the risk of one for diseases like diabetes, heart diseases, and hypertension [2]. Recent trends on weight reduction have shown dramatic decrease in the relative health risk associated with obesity. There are many options available today to address the obesity problem, these includes weight losing pills, exercises, dietary modifications, and bariatric surgery.
Patient Information
Definition
Obesity is a broad term that is used to describe a complex medical condition involving excessive amounts of body and visceral fats.
Cause
The cause of obesity can vary from genetic causes to hormonal influence, it can also be due to physical inactivity, as a side effect of excessive usage of few medications, secondary to few medical conditions, post pregnancy, and due to lack of proper sleep.
Symptoms
The symptoms of obesity can vary widely from breathlessness, muscle and joint pains, feeling tired often, irregular periods in females, varicose veins, and skin infections.
Diagnosis
Diagnosis includes detailed clinical history and physical examination, anthropometric measurements, blood tests to rule out secondary medical conditions, and ECG.
Treatment
Treatment includes treatment of secondary medical conditions, weight loss programs, dietary modifications, exercise, weight loss medications, and bariatric surgery.
References
- Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA. Feb 1 2012; 307(5):491-7.
- Nainggolan L. FDA Approves Bupropion/Naltrexone (Contrave) for Obesity. Medscape Medical News. Accessed November 15, 2014.
- Yaemsiri S, Slining MM, Agarwal SK. Perceived weight status, overweight diagnosis, and weight control among US adults: the NHANES 2003-2008 Study. Int J Obes (Lond). Aug 2011; 35(8):1063-70.
- Masters RK, Reither EN, Powers DA, Yang YC, Burger AE, Link BG. The Impact of Obesity on US Mortality Levels: The Importance of Age and Cohort Factors in Population Estimates. Am J Public Health. Aug 15 2013.
- Molarius A, Seidell JC, Sans S, Tuomilehto J, Kuulasmaa K. Waist and hip circumferences, and waist-hip ratio in 19 populations of the WHO MONICA Project. Int J Obes Relat Metab Disord. Feb 1999; 23(2):116-25.
- Martinelli CE, Keogh JM, Greenfield JR, Henning E, van der Klaauw AA, Blackwood A, et al. Obesity due to melanocortin 4 receptor (MC4R) deficiency is associated with increased linear growth and final height, fasting hyperinsulinemia, and incompletely suppressed growth hormone secretion. J Clin Endocrinol Metab. Jan 2011; 96(1):E181-8.
- Ketterer C, Heni M, Thamer C, Herzberg-Schäfer SA, Häring HU, Fritsche A. Acute, short-term hyperinsulinemia increases olfactory threshold in healthy subjects. Int J Obes (Lond). Aug 2011; 35(8):1135-8.
- Allison DB, Fontaine KR, Manson JE, Stevens J, VanItallie TB. Annual deaths attributable to obesity in the United States. JAMA. Oct 27 1999; 282(16):1530-8.
- Li C, Ford ES, Zhao G, Croft JB, Balluz LS, Mokdad AH. Prevalence of self-reported clinically diagnosed sleep apnea according to obesity status in men and women: National Health and Nutrition Examination Survey, 2005-2006. Prev Med. Jul 2010; 51(1):18-23.
- Jolly K, Lewis A, Beach J, et al. Comparison of range of commercial or primary care led weight reduction programmes with minimal intervention control for weight loss in obesity: Lighten Up randomised controlled trial. BMJ. Nov 3 2011; 343:d6500.