Presentation
Presentation[12] Early recognition is essential. Presenting features may be nonspecific and vague. A high degree of vigilance is therefore required at all times. Patients may have presented a few days earlier with a focus of infection. [patient.info]
We report a fatal case of M. haemolytica septicemia in a seven-month-old infant who presented with prolonged fever, sepsis, and pneumonitis without discernable preceding history of animal bites or contact. [ncbi.nlm.nih.gov]
(Present on Admission - Yes) Jan 2016 to Dec 2016 Medicare Hospitalizations (Present on Admission - Yes) Jan 2013 to Dec 2017 National Projected Hospitalizations (Present on Admission - Not Y) Jan 2016 to Dec 2016 Medicare Hospitalizations (Present on [dexur.com]
Entire Body System
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Fever
The typical course for cases of bacterial superinfection involves a second peak of high fever; other clinical signs are variable. Septicemia after rotavirus gastroenteritis is a rare but dangerous entity. [ncbi.nlm.nih.gov]
Synonyms: blood poisoning, septicaemia Types: show 5 types... hide 5 types... childbed fever, puerperal fever serious form of septicemia contracted by a woman during childbirth or abortion (usually attributable to unsanitary conditions); formerly widespread [vocabulary.com]
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Chills
A previously healthy, 67-year-old, man with past medical history of myocardial infarction and hypertension was rushed to the emergency room after sudden onset of fever, chills, severe rigors, hypotension, tachycardia and vomiting. [ncbi.nlm.nih.gov]
Symptoms Most patients have fever and chills, often of abrupt onset. However, some patients may be hypothermic (low temperature). Patients may breathe more rapidly and have changes in mental status (how they think, their alertness, etc.). [healthcentral.com]
Symptoms include chills, high fever, and rapid breathing and heart rate, and it can progress quickly to confusion, altered mental state, and shock. Seeking early medical treatment for infections is key to preventing septicemia. [alabamapublichealth.gov]
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Weakness
The reason is their immune systems are so weak that they fail to fight off the infection. Septic shock Septic is the serious drop in blood pressure resulted from toxins the bacteria release in the blood stream. [pacificcross.com.vn]
The signs and symptoms of Septicemia are varied, and can include sudden onset of fever, rapid breathing, accelerated heart rate, anxiety, and general weakness. [dovemed.com]
The onset of septicemia is signaled by a high fever, chills, weakness, and excessive sweating, followed by a decrease in blood pressure. [britannica.com]
Septicemia can cause fever, chills, rapid breathing, rapid heart rate, weakness, decreased urine output, and confusion or changes to a person’s mental state. [kidshealth.org]
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Falling
The blood pressure starts to fall and the person may lapse into unconsciousness. The skin becomes very pale and the person may exhibit petechiae. Petechiae are tiny spots on the skin, which do not blanch when a glass tumbler is applied to the skin. [irishhealth.com]
Symptoms of Septicemia The symptoms of septicemia are: Spiking fevers Chills Rapid breathing Elevated heart rate Shock Fever Decreased body temperature Falling blood pressure Confusion Changes in mental stability Blood clotting Decrease urine output to [foodpyramid.com]
Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were "to provide a conceptual and a practical framework to define the systemic inflammatory response to infection, which is a progressive injurious process that falls [ncbi.nlm.nih.gov]
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Shivering
These might include: high temperature extreme tiredness violent shivering and chills faintness pale and clammy skin rapid and shallow breathing The skin may also develop pinprick bruises (called petechiae) or large purple areas (called purpura), which [gosh.nhs.uk]
A high temperature A temperature of 38 C or higher or cold hands and feet and is shivering. Dislikes bright lights Squints or covers their eyes when exposed to light. [www2.hse.ie]
Adults with sepsis might experience one or more of the following symptoms: Fast breathing Fast heartbeat Skin rash or clammy/sweaty skin Weakness or aching muscles Not passing much (or any) urine Feeling very hot or cold, chills or shivering Feeling confused [health.qld.gov.au]
Early signs of sepsis include: fever, shivering, or feeling cold fast heart rate fast breathing and shortness of breath sweaty or clammy skin changes in mental state, such as feeling sleepy, confused, or losing interest If medical attention is not accessed [medicalnewstoday.com]
Respiratoric
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Tachypnea
Fever, chills, tachycardia (rapid heart beat), and tachypnea (rapid respirations) are common acute symptoms of septicemia. When hypotension (low blood pressure) and signs of inadequate organ perfusion develop, the condition is termed septic shock. [healthcentral.com]
SIRS• Two or more of the following conditions:– Fever or hypothermia– Tachypnea– Tachycardia– Leukocytosis or leukopenia or 10% bands• Infectious / Noninfectious6 7. Sepsis• SIRS with proven or suspected microbialetiology7 8. [slideshare.net]
[derived from Glasgow Coma Score 13]) while SIRS (including tachycardia 90 and tachypnea 20) criteria is deleted. [medintensiva.org]
By analyzing a large database of hospitalized patients, three clinical elements (hypotension, altered mentation, and tachypnea) were identified that could be used at the bedside to recognize those infected patients who are at risk of deteriorating or [doi.org]
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Common Cold
Children with SCID may also become infected with viruses (cytomegalovirus) from breastmilk, other live viruses (for example, the rotavirus or chickenpox) from vaccination or from common colds (viruses or bacteria) from siblings or surrounding children [rarediseases.org]
Gastrointestinal
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Vomiting
A previously healthy, 67-year-old, man with past medical history of myocardial infarction and hypertension was rushed to the emergency room after sudden onset of fever, chills, severe rigors, hypotension, tachycardia and vomiting. [ncbi.nlm.nih.gov]
Seek urgent medical care if your child has: a fit rapid breathing discoloured skin, very pale or bluish a rash that doesn’t fade when you press it fever OR very low temperature not passing urine (or no wet nappy) for several hours vomiting repeatedly [healthdirect.gov.au]
It also may progress into septicemia, a more serious blood infection that is always accompanied by symptoms such as chills, high fever, rapid heartbeat, severe nausea, vomiting and confusion. [orasurgery.com]
She had just returned from a visit out of the country when she developed nausea with vomiting and fever. On admission, the patient presented with fever and tachycardia and was placed on sepsis protocol. [icd10monitor.com]
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Abdominal Pain
Symptoms of sepsis include fever, high heart rate, rapid breathing, mental changes, abdominal pain, low blood pressure and potentially more severe complications. What are sepsis care options? Sepsis is a medical emergency. [nicklauschildrens.org]
‘Gastrointestinal anthrax is characterized by severe abdominal pain followed by fever and signs of septicemia.’ [oxforddictionaries.com]
When there are symptoms, they can include: Sudden high fever with chills Generally feeling unwell Gastrointestinal symptoms including nausea, vomiting and diarrhoea Abdominal pain Confusion and anxiety Shortness of breath Rapid heart rate (tachycardia [betterhealth.vic.gov.au]
nausea, vomiting, anorexia, abdominal pain) Physical examination Fever (temperature 100.4F (38.0C), tachycardia, hypotension Costovertebral angle tenderness Possible abdominal or suprapubic tenderness Laboratory tests Urinalysis showing positive leukocyte [icd10monitor.com]
However, fever (40.0 C), hypoxemia, tachycardia, shortness of breath, and abdominal pain developed on day 13. [nejm.org]
Liver, Gall & Pancreas
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Jaundice
Jaundice What other disease/condition shares some of these symptoms? Clinical signs and symptoms of septicemia are non-specific and overlap with findings in other diseases. [clinicaladvisor.com]
Sepsis-associated hepatic dysfunction is clinically recognized by jaundice or cholestasis and is caused by various underlying mechanisms such as the impairment of energy-dependent bile and bile acid transport by hypoxia, hypoperfusion, and overproduced [doi.org]
[…] not breastfeeding well low body temperature apnea (temporary stopping of breathing) fever pale color poor skin circulation with cool extremities abdominal swelling vomiting diarrhea seizures jitteriness yellowing of the skin and whites of the eyes (jaundice [healthline.com]
Impaired utilization of oxygen in the liver impairs bile salt transport, causing jaundice (yellowish discoloration of skin). [en.wikipedia.org]
Cardiovascular
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Hypotension
Management of hypotension• Vasopressor therapy– Titrating dose of norepinephrine or dopamine– Dobutamine if myocardial dysfunction28 29. [slideshare.net]
When hypotension (low blood pressure) and signs of inadequate organ perfusion develop, the condition is termed septic shock. [healthcentral.com]
Heparin was given in all patients with hypotension suspected of having the defect. Most patients with septicemia and low blood pressure apparently have the defect. [nejm.org]
A previously healthy, 67-year-old, man with past medical history of myocardial infarction and hypertension was rushed to the emergency room after sudden onset of fever, chills, severe rigors, hypotension, tachycardia and vomiting. [ncbi.nlm.nih.gov]
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Tachycardia
A previously healthy, 67-year-old, man with past medical history of myocardial infarction and hypertension was rushed to the emergency room after sudden onset of fever, chills, severe rigors, hypotension, tachycardia and vomiting. [ncbi.nlm.nih.gov]
On admission, the patient presented with fever and tachycardia and was placed on sepsis protocol. Workup showed leukocytosis and normal lactic acid. CT of abdomen demonstrated right pyelonephritis. [icd10monitor.com]
Fever, chills, tachycardia (rapid heart beat), and tachypnea (rapid respirations) are common acute symptoms of septicemia. When hypotension (low blood pressure) and signs of inadequate organ perfusion develop, the condition is termed septic shock. [healthcentral.com]
SIRS• Two or more of the following conditions:– Fever or hypothermia– Tachypnea– Tachycardia– Leukocytosis or leukopenia or 10% bands• Infectious / Noninfectious6 7. Sepsis• SIRS with proven or suspected microbialetiology7 8. [slideshare.net]
Musculoskeletal
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Myalgia
The initial symptoms of acute disease are often nonspecific and include fever, malaise, and myalgias but rapid deterioration leading to septic shock, multiorgan failure and death within hours of symptom onset can occur. [dermatologyadvisor.com]
History and Findings on Admission The 36-year-old male patient had malaise, headache, myalgias, and arthralgias on day 1 of the illness (August 18, 2014). Fever developed on day 2, and the patient was treated empirically for malaria. [nejm.org]
Skin
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Petechiae
Abstract Acute meningococcemia is characterized by extensive purpurae consisting of both petechiae and ecchymoses. This condition can be rapidly fatal without treatment due to shock and severe consumptive coagulopathy. [ncbi.nlm.nih.gov]
By multivariate analyses, a short onset to admission time, 50 petechiae, thrombocytopenia and severe septicaemia on admission were associated with fatality. [dictionary.cambridge.org]
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Skin Rash
Adults with sepsis might experience one or more of the following symptoms: Fast breathing Fast heartbeat Skin rash or clammy/sweaty skin Weakness or aching muscles Not passing much (or any) urine Feeling very hot or cold, chills or shivering Feeling confused [health.qld.gov.au]
In general, symptoms of sepsis can include: Chills Confusion or delirium Fever or low body temperature ( hypothermia ) Lightheadedness due to low blood pressure Rapid heartbeat Skin rash or mottled skin Warm skin A person with sepsis will be admitted [medlineplus.gov]
Alopecia and skin rash may be present depending on the form (e.g. SCID due to gamma chain deficiency or SCID due to JAK3 deficiency; see this term). Patients are unable to produce specific antibodies after vaccination or natural infection. [orpha.net]
Urogenital
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Oliguria
Organ dysfunction causes additional symptoms and signs specific to the organ involved (eg, oliguria, dyspnea). [merckmanuals.com]
Renal Complications Oliguria Azotaemia Proteinuria Nonspecific casts 32. [slideshare.net]
[…] of the body, most readily seen in the fingers/arms, toes/legs Sepsis is diagnosed when there is an infection somewhere in the body AND one of the following: Organ dysfunction (organ failure) Hypoxemia (inability to circulate oxygen to your tissues) Oliguria [christopherreeve.org]
[…] count with 10% immature forms Plasma C-reactive protein increase Plasma procalcitonin increase Hemodynamic variables Arterial hypotension SvO2 70% Cardiac index 3.5 L/min/m2 Organ dysfunction variables Arterial hypoxemia Acute oliguria [ekjm.org]
[…] included. 10 All but two trials included patients with both sepsis and organ failure (severe sepsis). 10 51 The definitions of organ failure varied slightly between trials, but in most included various clinical signs of hypoperfusion as, for example, oliguria [doi.org]
Neurologic
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Confusion
If you're confused about what exactly your doctor means, you should ask her to explain. Septicemia is a bacterial infection that spreads into the bloodstream. [verywellhealth.com]
If you're confused about what exactly your doctor means, you should ask her to explain this to you. [surreyfirstaid.com]
Symptoms include chills, high fever, and rapid breathing and heart rate, and it can progress quickly to confusion, altered mental state, and shock. Seeking early medical treatment for infections is key to preventing septicemia. [alabamapublichealth.gov]
Early signs of sepsis include: fever, shivering, or feeling cold fast heart rate fast breathing and shortness of breath sweaty or clammy skin changes in mental state, such as feeling sleepy, confused, or losing interest If medical attention is not accessed [medicalnewstoday.com]
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Dizziness
Symptoms include a high fever, faintness and dizziness, and changes in consciousness. Without prompt treatment, septic shock can occur. This can be fatal. Antibiotics can treat many cases of sepsis effectively, but they need to be delivered fast. [medicalnewstoday.com]
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Altered Mental Status
Severe sepsis is diagnosed when the septic patient has organ dysfunction (for example, low or no urine flow, altered mental status). [rxlist.com]
Altered mental status in this otherwise healthy adult with no comorbid conditions would also have indicated metabolic encephalopathy in severe sepsis. [icd10monitor.com]
In spite of relative contraindications (gastroparesis and altered mental status), noninvasive ventilation was initiated. [nejm.org]
The most common symptoms include: Fever Headache Stiff neck There are often additional symptoms, such as Nausea Vomiting Photophobia (eyes being more sensitive to light) Altered mental status (confusion) Newborns and babies may not have or it may be difficult [cdc.gov]
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Lethargy
Clinical presentations were lethargy (96%), respiratory distress (80%) and bleeding diathesis (16%). Absolute neutrophil count The Author [2015]. Published by Oxford University Press. All rights reserved. [ncbi.nlm.nih.gov]
Physical problems may include lethargy, muscle weakness, breathlessness, chest pains, oedema, arthralgia, poor appetite, visual disturbance, sensory disturbance and recurrent infections. [patient.info]
Septicemia include: Sudden onset of high fever or low temperature, chills, profuse sweating Elevated heart rate (tachycardia) Rapid breathing, shortness of breath Low or high white blood cell count Nausea, vomiting, and diarrhea Confusion, anxiety Weakness, lethargy [dovemed.com]
Children may show signs of lethargy and decreased age-appropriate mental status. Neonatal sepsis (sepsis neonatorum) is suspected in neonates up to 28 days old if the rectal temperature is 100.4 F or higher. [rxlist.com]
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Headache
Headache and neck stiffness Has a very bad headache or a stiff neck Pain or body stiffness Has aches or pains - stomach, joint or muscle pain. Has a stiff body with jerking movements or a floppy lifeless body. [www2.hse.ie]
They can include: fever chills uncontrolled shaking rapid breathing and heart rate tiredness headaches If sepsis gets worse, symptoms can include: confusion or anxiety nausea and vomiting difficulty breathing mottled skin a sudden drop in blood pressure [healthdirect.gov.au]
[…] tachycardia) Rapid breathing, shortness of breath Low or high white blood cell count Nausea, vomiting, and diarrhea Confusion, anxiety Weakness, lethargy, general malaise, and drowsiness Dusky skin appearance Reduced urine output Decreased mental acuity Headaches [dovemed.com]
In addition, patients with meningococcemia may present with the classic symptoms and signs of bacterial meningitis, including headache, photophobia, neck stiffness and a positive Kernig’s (pain on extending the knee 135 degrees) and Brudzinski’s signs [dermatologyadvisor.com]
The most common symptoms include: Fever Headache Stiff neck There are often additional symptoms, such as Nausea Vomiting Photophobia (eyes being more sensitive to light) Altered mental status (confusion) Newborns and babies may not have or it may be difficult [cdc.gov]
Workup
Workup showed leukocytosis and normal lactic acid. CT of abdomen demonstrated right pyelonephritis. Blood culture grew gram-negative bacteremia, identified as E. coli. She was started on IV hydration and Zosyn. [icd10monitor.com]
As examples, one respondent reported using a remarkably high temperature of 40 C or higher to define fever and one reported that fever never triggered a septic workup (Table 2 ). [doi.org]
“Lack of efficacy of the urine culture as part of the initial workup of suspected neonatal sepsis”. Pediatr Infect Dis J. vol. 11. 1992. pp. 764-6. Visser, VE, Hall, RT. “Urine culture in the evaluation of suspected neonatal sepsis”. [clinicaladvisor.com]
Parson, Melissa, Cytokine Storm in the Pediatric Oncology Patient (section "Differential Diagnoses and Workup", Journal of Peddanana is a good idea and is not the same tric Oncology Nursing, 27(5) Aug/Sep 2010, 253–258. Sharma S, Steven M. [en.wikipedia.org]
Serum
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Hemoglobin Decreased
For added clarity: • Indicates a strong recommendation or “we recommend”; indicates a weak recommendation or “we suggest” • Give red blood cells when hemoglobin decreases to 7.0 g/dl ( 70 g/L) to target a hemoglobin of 7.0–9.0 g/dl in adults. (1 B ) – [ncbi.nlm.nih.gov]
decreases to 7.0 g/dL ( 70 g/L) to target a hemoglobin of 7.0–9.0 g/dL (70–90 g/L) in adults (Grade 1B). [doi.org]
Treatment
To discuss pharmacotherapy challenges encountered during treatment of a pediatric oncology patient with Burkholderia cepacia septicemia. [ncbi.nlm.nih.gov]
Early aggressive treatment increases the chance of survival and every hour that treatment is delayed increases mortality[1]. Sepsis is defined as life-threatening organ dysfunction due to a dysregulated host response to infection[2]. [patient.info]
Treatment options Septicaemia is treated with intravenous antibiotics. [betterhealth.vic.gov.au]
Prognosis
To identify patients at high risk and to characterize modifiable risk factors for septicemia, we examined the incidence, risk factors, and prognosis for septicemia in a large, representative group of U.S. dialysis patients. [ncbi.nlm.nih.gov]
Sepsis (Blood Poisoning) Provides information on this dangerous medical condition, the causes, symptoms, signs, diagnosis, treatment, prognosis and prevention. [curlie.org]
Etiology
Abstract Escherichia coli remains one of the most common etiologies of secondary peritonitis. CMY-2 is the most prevalent AmpC enzyme identified in nosocomial E. coli isolates causing bacteremia in Taiwan. [ncbi.nlm.nih.gov]
The etiology, pathogenesis, and treatment of meningitis in the newborn infant are reviewed briefly. To access this article, please choose from the options below [jpeds.com]
Abstract Detailed coagulation analyses in 36 pediatric cases of septicemia revealed 22 gram-negative and eight gram-positive infections, two Rocky Mountain spotted fevers, and four with no etiologic agent isolated. [nejm.org]
Pneumonia was the most common source, accounting for 55% of the final infectious etiologies in the culture-negative group. [dx.doi.org]
Epidemiology
An epidemiological study of septicemia-related deaths were conducted at a level 1 Trauma Centre from January 2011 to December 2011. A total of 201 patients died due to suspected septicemia. [ncbi.nlm.nih.gov]
For information on epidemiology (Factors influencing occurrence of disease) click here. For information on clinical signs click here. For information on diagnosis click here. For information on control click here. [msd-animal-health.ie]
Taljaard: Associate Professor, School of Epidemiology and Public Health, University of Ottawa, Clinical Epidemiology Program, Ottawa Hospital Research Institute, 1053 Carling Avenue, Civic Box 693, Admin Services Building, Ottawa, Ontario K1Y 4E9, Canada [doi.org]
Pathophysiology
Furthermore, we review the recent advance in knowledge of sepsis pathophysiology, focusing on immune modulation, which may lead to new clinical therapeutic approach to sepsis. [doi.org]
Quantitative blood culture methods were used in early studies of bacterial endocarditis, and the results significantly contributed to our understanding of the pathophysiology of this disease. [cmr.asm.org]
Sepsis remains to be a significant health care issue associated with high mortality and healthcare cost, despite the extensive effort to better understand the pathophysiology of the sepsis. [ncbi.nlm.nih.gov]
Every year, billions of dollars are consumed in the treatment of sepsis and in research to understand its complex pathophysiology and therefore obtain future therapeutic opportunities. [dx.doi.org]
Prevention
PREVENTION : Treating wounds Treating infections Regular dental checkup 14. [slideshare.net]
This plan includes an analysis of the risks posed by the various pathways, or vectors, for transmission of the virus; a listing of known measures to prevent or contain the virus; an overall plan for the prevention of or response to the virus in the four [nps.gov]
Diagnosing it early may prevent septicemia from worsening to shock. [indiatoday.in]
Septicemia or sepsis is a medical emergency and is often preventable. The elderly, young, and those with a weaker immune system are more at risk. Learn about who else is at risk, symptoms to recognize, and what to do. [qvitahealthandwellness.com]